During the past project period, CCSG development funds were provided to launch the Survey and Biospecimen Shared Resource (SBSR). The SBSR provides high-quality laboratory and survey services to support Vanderbilt investigators conducting epidemiologic, clinical, and other population-based research. Major services provided by the SBSR include consultation for study design and protocol development, processing of biological samples, DNA extraction, biospecimen storage and requisition, genotyping assays, project management, interviewer-administered telephone surveys, web-based surveys, and other data collection methods. Most epidemiologic and clinical investigators do not have their own laboratories and are unfamiliar with laboratory operations. At the same time, most basic science labs are unequipped to handle the large volume of samples in epidemiologic studies. Furthermore, most clinical investigators do not have the expertise, time or resources to develop questionnaires, data collection systems, and study procedures. The SBSR enables investigators to access significant expertise and experience in epidemiologic research, avoid the start-up costs associated with hiring and training staff for data collection and sample processing, and share experienced research staff with other projects to reduce study costs. By implementing rigorous quality control protocols, SBSR significantly enhances the quality in data and specimen collection and processing. In its first year of operation, the SBSR has provided high quality services to more than 20 VICC members and supported research for multiple large studies, including three large cohort studies and two SPORE projects. The growth of the SBSR continues to escalate with the expansion of population and translational research at the VICC. The leadership team for the SBSR is composed of three investigators with extensive experience in epidemiology studies of lifestyle factors and biomarkers for cancer. Wei Zheng, Ph.D., is the senior scientific director for the SBSR. Qiuyin Cai, Ph.D., is the scientific co-director overseeing operations for the laboratory services, while Martha Shrubsole, Ph.D. is the scientific co-director responsible for survey research services These investigators each bring unique and complementary expertise and knowledge to ensure the efficient operation of this highly functional shared resource.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA068485-18
Application #
8733545
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
18
Fiscal Year
2014
Total Cost
$165,637
Indirect Cost
$89,303
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Zhao, Shilin; Li, Chung-I; Guo, Yan et al. (2018) RnaSeqSampleSize: real data based sample size estimation for RNA sequencing. BMC Bioinformatics 19:191
Croessmann, Sarah; Sheehan, Jonathan H; Lee, Kyung-Min et al. (2018) PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3K? Inhibitors. Clin Cancer Res 24:1426-1435
Pannala, Venkat R; Wall, Martha L; Estes, Shanea K et al. (2018) Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat. Sci Rep 8:11678
Salisbury-Ruf, Christi T; Bertram, Clinton C; Vergeade, Aurelia et al. (2018) Bid maintains mitochondrial cristae structure and function and protects against cardiac disease in an integrative genomics study. Elife 7:
Laroumanie, Fanny; Korneva, Arina; Bersi, Matthew R et al. (2018) LNK deficiency promotes acute aortic dissection and rupture. JCI Insight 3:
Doxie, Deon B; Greenplate, Allison R; Gandelman, Jocelyn S et al. (2018) BRAF and MEK inhibitor therapy eliminates Nestin-expressing melanoma cells in human tumors. Pigment Cell Melanoma Res 31:708-719
Phelps, Hannah M; Al-Jadiry, Mazin F; Corbitt, Natasha M et al. (2018) Molecular and epidemiologic characterization of Wilms tumor from Baghdad, Iraq. World J Pediatr 14:585-593
Liu, Qi; Herring, Charles A; Sheng, Quanhu et al. (2018) Quantitative assessment of cell population diversity in single-cell landscapes. PLoS Biol 16:e2006687
Burns, Michael C; Howes, Jennifer E; Sun, Qi et al. (2018) High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal Biochem 548:44-52
Greenplate, Allison; Wang, Kai; Tripathi, Rati M et al. (2018) Genomic Profiling of T-Cell Neoplasms Reveals Frequent JAK1 and JAK3 Mutations With Clonal Evasion From Targeted Therapies. JCO Precis Oncol 2018:

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