) Basic research in the Molecular Oncology Program is directed at understanding molecular mechanisms of oncogenesis with a view toward development of more effective cancer therapies. This goal is being achieved through research related to the program?s three focus areas: (1) signal transduction from the cell surface to the nucleus, (2) nuclear transcription factors and regulation of gene expression, and (3) discovery of new drugs to treat cancer based on targeting signal transduction and gene control mechanisms. In addition to providing scientific focus and leadership, the Program Leader?s efforts are directed at stimulation of interdisciplinary and translational studies involving both intra- and inter-programmatic collaborations. The Molecular Oncology Program comprises 21 faculty members, the majority of whom have been recruited in recent years from outside institutions. Research in this program is funded by $4,3 million in annual direct costs, most of which is peer-reviewed, including over $3,2 million from NCI and all other NIH. One program project grant in cancer drug discovery is funded by NCI, representing an intra-programmatic collaborative effort, and another program project in molecular oncology with a strong translational focus, representing an inter-programmatic collaboration, is pending review by NCI. The program members have been highly productive, with significant numbers of joint publications resulting from intra- and inter-programmatic collaborations. This tremendous progress in the Molecular Oncology Program has been greatly facilitated by the Cancer Center?s continuing commitment in terms of new faculty recruitment and development of the research infrastructure, including state-of-the-art core facilities. Plans for the future include additional recruitment of new faculty to further strengthen drug discovery and cancer genetics.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of South Florida
United States
Zip Code
Hellmann, Matthew D; Callahan, Margaret K; Awad, Mark M et al. (2018) Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer. Cancer Cell 33:853-861.e4
Trabert, Britton; Poole, Elizabeth M; White, Emily et al. (2018) Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium. J Natl Cancer Inst :
Palmer, Amanda M; Brandon, Thomas H (2018) How do electronic cigarettes affect cravings to smoke or vape? Parsing the influences of nicotine and expectancies using the balanced-placebo design. J Consult Clin Psychol 86:486-491
Dougoud-Chauvin, Vérène; Lee, Jae Jin; Santos, Edgardo et al. (2018) Using Big Data in oncology to prospectively impact clinical patient care: A proof of concept study. J Geriatr Oncol 9:665-672
Wu, Xiaowei; Ji, Haitao (2018) Rhodium(iii)-catalyzed C-H allylation of indoles with allyl alcohols via ?-hydroxide elimination. Org Biomol Chem 16:5691-5698
Liu, Ying; Kim, Jongphil; Balagurunathan, Yoganand et al. (2018) Prediction of pathological nodal involvement by CT-based Radiomic features of the primary tumor in patients with clinically node-negative peripheral lung adenocarcinomas. Med Phys 45:2518-2526
Davis, Stacy N; Govindaraju, Swapamthi; Jackson, Brittany et al. (2018) Recruitment Techniques and Strategies in a Community-Based Colorectal Cancer Screening Study of Men and Women of African Ancestry. Nurs Res 67:212-221
Martínez, Úrsula; Brandon, Thomas H; Sutton, Steven K et al. (2018) Associations between the smoking-relatedness of a cancer type, cessation attitudes and beliefs, and future abstinence among recent quitters. Psychooncology 27:2104-2110
Perales-Puchalt, Alfredo; Perez-Sanz, Jairo; Payne, Kyle K et al. (2018) Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol 103:799-805
Nelson, Ashley M; Jim, Heather S L; Small, Brent J et al. (2018) Sleep disruption among cancer patients following autologous hematopoietic cell transplantation. Bone Marrow Transplant 53:307-314

Showing the most recent 10 out of 1254 publications