The goal of the Informatics Core is based on bioinformatics as defined by NIH as research, development, or application of computational tools and approaches for expanding the use of biological, medical, behavioral or health data, including those to acquire, store, organize, archive, analyze, or visualize such data. The Informatics Core Facility provides the following services to Center members: Data Modeling for Organization of Data - development and use of a structured, cancer based data model that captures and relates events in any cancer patient's medical history as it unfolds from a first time diagnosis through a series of tests, test results, and linked therapies and experimental results. Database Design and Implementation for Storage of Data - modular design of databases for users based on the generalized data model for cancer research. User Interfaces for Visualization of Data - design and implementation of web interfaces to data repositories to accommodate reports and data downloads, as they would be requested by users ranging from clinical investigators to computer scientists. Parallel Computation - expertise in development and adaptation of algorithms for parallel computation using any of several Beowolf style supercomputers. Data Mining and Pattern Analysis - expertise in machine learning and genetic algorithms that can be used to analyze high dimensional data where the number of measured values far exceeds the number of samples and reduce it to a set of features and hypothesized relationships that are amenable to subsequent rigorous testing by the Biostatistics Core. Annotation - clinical annotation of human tissues, and structural and functional annotation of molecular profiles. Integration with CaBIG - integration of CaBIG tools both in official role as Integrative Cancer Workspace adopter and as a leader in the development of data standards and structured tools for cancer informatics. Dr. Mary E. Edgerton is responsible for the scientific operations of the Informatics Core. She is aided by a staff of bioinformatician faculty and staff scientists, a software specialist, an expanding group of software developers, a systems administrator, and a resource manager. In addition to directly supporting the research community, the Informatics Core has close collaborative interactions with the Tissue, Microarray, Proteomics, Analytic Microscopy, HTS &Chemistry Core and Biostatistics Core.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA076292-12
Application #
8055333
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2010-02-01
Budget End
2011-01-31
Support Year
12
Fiscal Year
2010
Total Cost
$182,190
Indirect Cost
Name
H. Lee Moffitt Cancer Center & Research Institute
Department
Type
DUNS #
139301956
City
Tampa
State
FL
Country
United States
Zip Code
33612
Davis, Stacy N; Govindaraju, Swapamthi; Jackson, Brittany et al. (2018) Recruitment Techniques and Strategies in a Community-Based Colorectal Cancer Screening Study of Men and Women of African Ancestry. Nurs Res 67:212-221
Martínez, Úrsula; Brandon, Thomas H; Sutton, Steven K et al. (2018) Associations between the smoking-relatedness of a cancer type, cessation attitudes and beliefs, and future abstinence among recent quitters. Psychooncology 27:2104-2110
Perales-Puchalt, Alfredo; Perez-Sanz, Jairo; Payne, Kyle K et al. (2018) Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol 103:799-805
Nelson, Ashley M; Jim, Heather S L; Small, Brent J et al. (2018) Sleep disruption among cancer patients following autologous hematopoietic cell transplantation. Bone Marrow Transplant 53:307-314
Singh, Kshipra; Coburn, Lori A; Asim, Mohammad et al. (2018) Ornithine Decarboxylase in Macrophages Exacerbates Colitis and Promotes Colitis-Associated Colon Carcinogenesis by Impairing M1 Immune Responses. Cancer Res 78:4303-4315
Kasting, Monica L; Giuliano, Anna R; Reich, Richard R et al. (2018) Hepatitis C Virus Screening Trends: Serial Cross-Sectional Analysis of the National Health Interview Survey Population, 2013-2015. Cancer Epidemiol Biomarkers Prev 27:503-513
Denson, Aaron; Burke, Nancy; Wapinsky, Georgine et al. (2018) Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials. Am J Clin Oncol 41:133-139
Betts, Brian C; Bastian, David; Iamsawat, Supinya et al. (2018) Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. Proc Natl Acad Sci U S A 115:1582-1587
Pidala, Joseph; Beato, Francisca; Kim, Jongphil et al. (2018) In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation. Haematologica 103:531-539
Hampras, S S; Tommasino, M; Zhao, Y et al. (2018) Cross-sectional associations between cutaneous viral infections and regulatory T lymphocytes in circulation. Br J Dermatol :

Showing the most recent 10 out of 1254 publications