The Chemical Biology Core assists researchers in identifying and optimizing chemical probes and new lead compounds that can aid drug discovery &development and ultimately provide therapeutic benefit to cancer patients. The core is comprised of four functional units: ? Experimental High Throughput Screening Unit (Experimental HTS lab) ? Virtual HTS and Molecular Modeling Unit (Virtual HTS lab) ? Chemical Intermediates and Library Synthesis Unit (Chemistry lab) ? Protein Crystallography Unit (Protein Crystallography, being added recently) Over the last five years, the core developed the Protein Crystallography Unit, which provides all services needed from cloning the DNA sequence to determining the crystal structure. The addition of the Protein Crystallography Unit led to the renaming of the HTS &Chemistry core to """"""""Chemical Biology Core"""""""". In 2007, Moffitt recruited Ernst Schonbrunn, PhD, to lead this unit and serve as Co-Scientific Director with Dr. Guida. Under their joint leadership and due to the substantially increased demand for x-ray usage, additional equipment was acquired, including an upgraded X-ray generator in 2009. The Core requests CCSG Support of $363,941, which is 42% of its operational budget. Usage has grown to 22 active projects and Over 90% of usage is by Moffitt members and peer-reviewed.

Public Health Relevance

The Chemical Biology core provides four fundamental services to enhance the research for Moffitt investigators that significantly impact the drug discovery process. Core has been highly successful in stimulating Cancer Center investigators grant applications in chemical biology approaches to cancer studies. In addition, the shared resource provides access to many kinds of equipment that are too expensive for the average laboratory to own individually.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
H. Lee Moffitt Cancer Center & Research Institute
United States
Zip Code
Denson, Aaron; Burke, Nancy; Wapinsky, Georgine et al. (2018) Clinical Outcomes of Patients With Gastrointestinal Malignancies Participating in Phase I Clinical Trials. Am J Clin Oncol 41:133-139
Betts, Brian C; Bastian, David; Iamsawat, Supinya et al. (2018) Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation. Proc Natl Acad Sci U S A 115:1582-1587
Pidala, Joseph; Beato, Francisca; Kim, Jongphil et al. (2018) In vivo IL-12/IL-23p40 neutralization blocks Th1/Th17 response after allogeneic hematopoietic cell transplantation. Haematologica 103:531-539
Hampras, S S; Tommasino, M; Zhao, Y et al. (2018) Cross-sectional associations between cutaneous viral infections and regulatory T lymphocytes in circulation. Br J Dermatol :
Rockfield, Stephanie; Flores, Idhaliz; Nanjundan, Meera (2018) Expression and function of nuclear receptor coactivator 4 isoforms in transformed endometriotic and malignant ovarian cells. Oncotarget 9:5344-5367
Hoogland, Aasha I; Lechner, Suzanne C; Gonzalez, Brian D et al. (2018) Efficacy of a Spanish-Language Self-Administered Stress Management Training intervention for Latinas undergoing chemotherapy. Psychooncology 27:1305-1311
Karolak, Aleksandra; Estrella, Veronica C; Huynh, Amanda S et al. (2018) Targeting Ligand Specificity Linked to Tumor Tissue Topological Heterogeneity via Single-Cell Micro-Pharmacological Modeling. Sci Rep 8:3638
Barata, Anna; Gonzalez, Brian D; Sutton, Steven K et al. (2018) Coping strategies modify risk of depression associated with hematopoietic cell transplant symptomatology. J Health Psychol 23:1028-1037
Karolak, Aleksandra; Rejniak, Katarzyna A (2018) Micropharmacology: An In Silico Approach for Assessing Drug Efficacy Within a Tumor Tissue. Bull Math Biol :
Kazi, Aslamuzzaman; Xiang, Shengyan; Yang, Hua et al. (2018) GSK3 suppression upregulates ?-catenin and c-Myc to abrogate KRas-dependent tumors. Nat Commun 9:5154

Showing the most recent 10 out of 1254 publications