An important cancer research challenge is accessing substantial quantities of patient data collected while providing clinical care. At the last CCSG review, the reviewers encouraged the Moffitt Cancer Center (MCC) to develop a service facilitating member access to the data customarily collected on all cancer patients that is needed to conduct high-impact transdisciplinary research. As a result, in 2013, the MCC developed a core expressly designed to facilitate access to patient data, leveraging the MCC enterprise-wide Heath Research Informatics (HRI) data warehouse with discretely captured patient-level data (e.g., patient questionnaires, cancer registry, electronic health records, billing, and the Tissue Core biospecimen archive) on over 475,000 MCC patients. This MCC initiative developed the Collaborative Data Services Core (CDSC), now a fully- functioning core. The CDSC is a unique shared resource that facilitates MCC member use of patient-reported clinical, tumor, and biospecimen data in support of innovative research across all research programs. The CDSC supports members with three primary services: consultation, data provisioning, and study-specific medical record abstraction.
The specific aims that drive the CDSC are to: 1) Promote and facilitate cutting-edge translational research by providing members access to high- quality discrete patient-level data linked within MCC's enterprise-wide data warehouse and cost-efficient collection of clinical data from patient medical records; 2) Assist investigators at the early stages of developing research projects with consultations on study data access and project feasibility through provisioning of aggregate count data from the MCC HRI data warehouse; 3) Promote data access and data provisioning by providing individual or small group training, workshops, and data concierge training. The CDSC is led by Scientific Director Erin Siegel, PhD, MPH, who has extensive experience conducting epidemiological studies utilizing the HRI resource. The CDSC is also supported by a Facility Director, a Core Manager, and six staff members. In fiscal year 2015, the CDSC fulfilled service requests for 79 members across all five CCSG programs, which represents 72% of the total usage; 47% of usage was in support of peer-review funded members. During the five-year project period, the CDSC has contributed to at least 102 peer-reviewed publications and 31 peer-reviewed funded grants. The CDSC provides unique data provisioning and manual data abstraction services integrated in a typical project workflow in collaboration with several shared resources, including the Tissue Core, Biostatistics Core, and Cancer Informatics Core; it provides members access to enterprise-wide patient data to conduct cutting-edge, high-impact translational and personalized medicine research.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
H. Lee Moffitt Cancer Center & Research Institute
United States
Zip Code
Kim, Youngchul; Pierce, Christine M; Robinson, Lary A (2018) Impact of viral presence in tumor on gene expression in non-small cell lung cancer. BMC Cancer 18:843
Persi, Erez; Duran-Frigola, Miquel; Damaghi, Mehdi et al. (2018) Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nat Commun 9:2997
Rosenberger, Albert; Hung, Rayjean J; Christiani, David C et al. (2018) Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners. Int Arch Occup Environ Health 91:937-950
Chen, Yan; Zhu, Jin-Yi; Hong, Kwon Ho et al. (2018) Structural Basis of ALDH1A2 Inhibition by Irreversible and Reversible Small Molecule Inhibitors. ACS Chem Biol 13:582-590
Kahen, Elliot John; Brohl, Andrew; Yu, Diana et al. (2018) Neurofibromin level directs RAS pathway signaling and mediates sensitivity to targeted agents in malignant peripheral nerve sheath tumors. Oncotarget 9:22571-22585
Hoffman, Melissa A; Fang, Bin; Haura, Eric B et al. (2018) Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res 17:63-75
Puri, Sonam; Hyland, Kelly A; Weiss, Kristine Crowe et al. (2018) Prediction of chemotherapy-induced nausea and vomiting from patient-reported and genetic risk factors. Support Care Cancer 26:2911-2918
Gonzalez, Brian D; Small, Brent J; Cases, Mallory G et al. (2018) Sleep disturbance in men receiving androgen deprivation therapy for prostate cancer: The role of hot flashes and nocturia. Cancer 124:499-506
Eroglu, Zeynep; Zaretsky, Jesse M; Hu-Lieskovan, Siwen et al. (2018) High response rate to PD-1 blockade in desmoplastic melanomas. Nature 553:347-350
Lu, Yingchang; Beeghly-Fadiel, Alicia; Wu, Lang et al. (2018) A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. Cancer Res 78:5419-5430

Showing the most recent 10 out of 1254 publications