During the past grant cycle, the Masonic Cancer Center (MCC) used developmental funds to support the following activities: ? 13 newly recruited investigators ? Pilot Projects: several MCC pilot mechanisms provide funding to aid in the development of multi-investigator research.
The aim i s to develop competitive applications to submit to the National Cancer Institute's Specialized Programs of Research Excellence (SPOREs), Program Project (P01), or similar grant programs ? Clinical Pharmacology Developing Shared Resource, which has become an established shared resource in this submission ? Translational Methodologies support enabled Dr. Gunda Georg, Director of the Institute for Therapeutics Discovery &Development, to generate a triptolide derivative (termed Minnelide) and to optimize its pharmacokinetic properties for use as a cancer therapeutic. Recent work demonstrated the efficacy of this drug in vivo. Minnelide has been licensed to Minneamrita Therapeutics LLC for production and will be in a clinical phase I trial in the first half of 2013 The MCC is proposing to use developmental funds for the following purposes in the upcoming funding period: ? Newly recruited faculty ? Pilot research ? Two developing shared resources o Recruitment and Retention: This shared resource will support investigators in developing recruitment plans for therapeutic and non-therapeutic studies and ensuring complete and timely enrollment of participants. o Genome Engineering: This shared resource will use recombinant adeno-associated virus (rAAV) and transcription activator-like effector nucleases (TALENs) to make site-specific alterations in human cell lines ofthe investigator's choosing. ? Staff Investigator: We are requesting funding for a 10% time Research Staff Investigator who will be responsible for developing the Cancer Detection, Treatment, and Survivorship (CaDeTS) component of the Prevention and Etiology Program to address a range of issues relevant to cancer patients and their families, including early detection through screening programs, comparative effectiveness and quality of cancer care across the continuum of care, and long-term quality-of-life outcomes of cancer survivors

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA077598-16
Application #
8633140
Study Section
Subcommittee G - Education (NCI)
Project Start
1998-06-01
Project End
2019-01-31
Budget Start
2014-03-05
Budget End
2015-01-31
Support Year
16
Fiscal Year
2014
Total Cost
$305,549
Indirect Cost
$61,605
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Guo, Jingshu; Villalta, Peter W; Weight, Christopher J et al. (2018) Targeted and Untargeted Detection of DNA Adducts of Aromatic Amine Carcinogens in Human Bladder by Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry. Chem Res Toxicol :
Boatman, Jeffrey A; Vock, David M; Koopmeiners, Joseph S et al. (2018) Estimating causal effects from a randomized clinical trial when noncompliance is measured with error. Biostatistics 19:103-118
Rashidi, Armin; Shanley, Ryan; Yohe, Sophia L et al. (2018) Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples. Br J Haematol 182:887-894
Teitelbaum, A M; Murphy, S E; Akk, G et al. (2018) Nicotine dependence is associated with functional variation in FMO3, an enzyme that metabolizes nicotine in the brain. Pharmacogenomics J 18:136-143
Murphy, Sharon E; von Weymarn, Linda B; Parenteau, Marc et al. (2018) Influence of UGT2B10 Genotype on Urinary Excretion of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol- N-glucuronide by African American Smokers. Chem Res Toxicol 31:168-175
Bellamri, Medjda; Xiao, Shun; Murugan, Paari et al. (2018) Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci 163:543-556
Jarvis, Matthew C; Ebrahimi, Diako; Temiz, Nuri A et al. (2018) Mutation Signatures Including APOBEC in Cancer Cell Lines. JNCI Cancer Spectr 2:
Hegerova, Livia; Bachan, Adam; Cao, Qing et al. (2018) Catheter-Related Thrombosis in Patients with Lymphoma or Myeloma Undergoing Autologous Stem Cell Transplantation. Biol Blood Marrow Transplant 24:e20-e25
Lassig, Amy Anne D; Bechtold, Joan E; Lindgren, Bruce R et al. (2018) Tobacco exposure and wound healing in head and neck surgical wounds. Laryngoscope 128:618-625
Petzel, Sue V; Isaksson Vogel, Rachel; Cragg, Julie et al. (2018) Effects of web-based instruction and patient preferences on patient-reported outcomes and learning for women with advanced ovarian cancer: A randomized controlled trial. J Psychosoc Oncol 36:503-519

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