Carcinogenesis and Chemoprevention Program Summary The scientific goals of the Carcinogenesis and Chemoprevention Program are to identify biomarkers for tobacco-related cancer risk; and to understand how environmental and dietary chemicals contribute to carcinogenesis through specific biochemical pathways and to apply this knowledge for individualized cancer risk stratification and cancer prevention. The ultimate objective is to translate these findings into investigator- initiated clinical trials that change public policy and health care. To achieve our goals, we have successful, mature research programs which address the following aims: 1) to characterize the harmful effects of tobacco chemicals and products and develop biomarkers for cancer risk stratification in clinical and epidemiological studies; 2) to understand how chemicals in food and medicine and specific biochemical pathways may contribute to carcinogenesis; 3) to identify food products, as well as natural and synthetic chemicals, that reduce cancer risk. Drs. Lisa Peterson and Frank Ondrey lead the Program, which has 24 members, representing 14 departments and 8 schools or colleges (College of Biological Sciences; College of Food, Agriculture and Natural Resources; College of Pharmacy; College of Science and Engineering; College of Veterinary Medicine; Hormel Institute; Medical School, and School of Public Health). In the last budget year, these members were supported by $5.6 million in direct costs from the National Cancer Institute; funding from all peer-reviewed sources totaled $8.2 million in direct costs. Since 2013, Program members have published 628 papers, 20% of which resulted from intraprogrammatic collaborations, 20% from interprogrammatic collaborations, and 87% from external collaborations. Since 2013, 53 clinical trials in all clinical research categories have opened under this programmatic area and have accrued 7728 subjects. The Masonic Cancer Center (MCC) has provided substantial value to the program, including access to shared resources, recruiting 3 new faculty, funding of 10 pilot projects ($382,500 awarded), 1 research retreat, 1 strategic planning meeting, 24 meetings on recent Program member research projects, 2 special seminars, and 2 meetings to discuss specific requests for proposals from the NIH. A monthly interprogrammatic translational biomarker focus group brings together population scientists and clinicians with basic research groups developing specific biomarkers. The Program's future direction fits well within the MCC's strategic plan. We will continue the translation of our basic research into chemoprevention clinical trials (Scientific Priority for Growth 3- SPG3). We are actively using biomarkers to understand carcinogenesis and to develop strategies to personalize cancer screening and treatments (SPG4). Program members are actively involved in the planning of the 10,000 Family cohort (SPG5), and this resource will be invaluable for the translation of our science to the catchment area. Lastly, we plan to use tobacco-related biomarkers to develop individually targeted smoking cessation and screening protocols in Minnesota's minority populations who have a disproportionate cancer burden (SPG6).

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA077598-22
Application #
9859366
Study Section
Subcommittee H - Clinical Groups (NCI)
Project Start
Project End
Budget Start
2020-02-01
Budget End
2021-01-31
Support Year
22
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Ma, Bin; Zarth, Adam T; Carlson, Erik S et al. (2018) Methyl DNA Phosphate Adduct Formation in Rats Treated Chronically with 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of Its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chem Res Toxicol 31:48-57
Hatsukami, Dorothy K; Luo, Xianghua; Jensen, Joni A et al. (2018) Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial. JAMA 320:880-891
Lee, Hak Rae; Leslie, Faith; Azarin, Samira M (2018) A facile in vitro platform to study cancer cell dormancy under hypoxic microenvironments using CoCl2. J Biol Eng 12:12
Yang, Libang; Herrera, Jeremy; Gilbertsen, Adam et al. (2018) IL-8 mediates idiopathic pulmonary fibrosis mesenchymal progenitor cell fibrogenicity. Am J Physiol Lung Cell Mol Physiol 314:L127-L136
Regan Anderson, Tarah M; Ma, Shihong; Perez Kerkvliet, Carlos et al. (2018) Taxol Induces Brk-dependent Prosurvival Phenotypes in TNBC Cells through an AhR/GR/HIF-driven Signaling Axis. Mol Cancer Res 16:1761-1772
Grzywacz, Bartosz; Moench, Laura; McKenna Jr, David et al. (2018) Natural Killer Cell Homing and Persistence in the Bone Marrow After Adoptive Immunotherapy Correlates With Better Leukemia Control. J Immunother :
Santiago, Victor; Lazaryan, Aleksandr; McClune, Brian et al. (2018) Quantification of marrow hematogones following autologous stem cell transplant in adult patients with plasma cell myeloma or diffuse large B-cell lymphoma and correlation with outcome. Leuk Lymphoma 59:958-966
Guo, Jingshu; Villalta, Peter W; Weight, Christopher J et al. (2018) Targeted and Untargeted Detection of DNA Adducts of Aromatic Amine Carcinogens in Human Bladder by Ultra-Performance Liquid Chromatography-High-Resolution Mass Spectrometry. Chem Res Toxicol :
Boatman, Jeffrey A; Vock, David M; Koopmeiners, Joseph S et al. (2018) Estimating causal effects from a randomized clinical trial when noncompliance is measured with error. Biostatistics 19:103-118
Rashidi, Armin; Shanley, Ryan; Yohe, Sophia L et al. (2018) Recipient single nucleotide polymorphisms in Paneth cell antimicrobial peptide genes and acute graft-versus-host disease: analysis of BMT CTN-0201 and -0901 samples. Br J Haematol 182:887-894

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