DNA The DNA Core located in the Eckstein Medical Research Building adjacent to the Holden Cancer Research Laboratories supports research performed by investigators in all HCCC programs. It provides a broad spectrum of services and resources designed to make the state-of-the-art techniques used in DNA sequence and transcript analysis readily available to the University of lowa research community. These services and resources include: 1) DNA sequencing, 2) custom oligonucleotides, 3) DNA microarrays using both the Affymetrix GeneChip system and the custom spotted array using the microscope slide format, 4) real-time PCR, 5) molecular biology computing, and 6) genome sequencing using next generation sequencing technologies. It is the aim of the DNA Core to provide high quality services to HCCC members with a rapid turnaround and support these services with well-trained personnel. The core also continues to evaluate andupdate their services so they remain cutting-edge and provides new services, as needed, to continue to meet the needs of HCCC investigators. In 2009, the DNA Core provided services to 82 HCCC members with peer reviewed funding.

Public Health Relevance

The DNA Core is highly cancer relevant. The services it provides, including state-of-the-art DNA sequencing, production of custom oligonucleotides, and microarray analysis, are necessary tools for the conduct of modern molecular cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA086862-12S1
Application #
8533960
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
2016-03-31
Budget Start
2012-05-03
Budget End
2013-03-31
Support Year
12
Fiscal Year
2012
Total Cost
$3,000
Indirect Cost
$1,013
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Curry, Susan J; Krist, Alex H; Owens, Douglas K (2018) Annual Report to the Nation on the Status of Cancer, Part II: Recent changes in prostate cancer trends and disease characteristics. Cancer :
Marsden, Autumn N; Derry, Sarah W; Schneider, Igor et al. (2018) The Nkd EF-hand domain modulates divergent wnt signaling outputs in zebrafish. Dev Biol 434:63-73
Rafiullah; Ali, Asad; Mohiuddin, Hafsa et al. (2018) Innovations in the Management of Hepatocellular Carcinoma. Am J Ther 25:e362-e368
Guy, Christopher L; Weiss, Elisabeth; Jan, Nuzhat et al. (2018) Technical Note: A method for quality assurance of landmark sets for use in evaluation of deformable image registration accuracy of lung parenchyma. Med Phys :
Vander Weg, Mark W; Coday, Mace; Stockton, Michelle B et al. (2018) Community-based physical activity as adjunctive smoking cessation treatment: Rationale, design, and baseline data for the Lifestyle Enhancement Program (LEAP) randomized controlled trial. Contemp Clin Trials Commun 9:50-59
Paul, Sanjoy; McDonald, W Hayes; Moye-Rowley, W Scott (2018) Negative regulation of Candida glabrata Pdr1 by the deubiquitinase subunit Bre5 occurs in a ubiquitin independent manner. Mol Microbiol 110:309-323
Swami, Umang; Zakharia, Yousef; Zhang, Jun (2018) Understanding Microbiome Effect on Immune Checkpoint Inhibition in Lung Cancer: Placing the Puzzle Pieces Together. J Immunother 41:359-360
Khakhina, Svetlana; Simonicova, Lucia; Moye-Rowley, W Scott (2018) Positive autoregulation and repression of transactivation are key regulatory features of the Candida glabrata Pdr1 transcription factor. Mol Microbiol 107:747-764
Weeks, Kristin S; Kahl, Amanda R; Lynch, Charles F et al. (2018) Racial/ethnic differences in thyroid cancer incidence in the United States, 2007-2014. Cancer 124:1483-1491
Carr, Prudence R; Banbury, Barbara; Berndt, Sonja I et al. (2018) Association Between Intake of Red and Processed Meat and Survival in Patients With Colorectal Cancer in a Pooled Analysis. Clin Gastroenterol Hepatol :

Showing the most recent 10 out of 1080 publications