Abstract

HCCC uses developmental funds to support promising research through pilot grants, new faculty recruitments, development of new shared research resources and support staff investigators in areas of particular promise and importance for HCCC research. This is done by combining developmental funds support with institutional and philanthropic resources. Interdisciplinary pilot grants are awarded to support new, collaborative cancer research ideas based on recommendations of the Program leaders. Developmental Funds are also used to support recruitment of both senior and junior faculty. Recruitment of senior level faculty focuses on areas where there is a particular need for scientific leadership within the HCCC. Developmental Funds are used to support new shared research resources. Examples of successful development from the prior funding period include the Molecular Epidemiology Resource (MER) and High Throughput Screening (HTS). Proposed developing cores include a comprehensive Imaging Core and a Functional Genomics Core. Support for Drs. Mohammed Milhem and Daniel Vaena in the past funding period allowed them to advance their careers and assume new leadership roles in the HCCC. Proposed support for Drs. Tricot and Lutgendorf will support their leadership roles in hematopoietic stem cell transplant and study of the relationship between psychosocial factors and the biology of cancer.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA086862-19
Application #
9690577
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
19
Fiscal Year
2019
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Yates, Luke A; Aramayo, Ricardo J; Pokhrel, Nilisha et al. (2018) A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA. Nat Commun 9:5447
Lynch, Thomas J; Anderson, Preston J; Rotti, Pavana G et al. (2018) Submucosal Gland Myoepithelial Cells Are Reserve Stem Cells That Can Regenerate Mouse Tracheal Epithelium. Cell Stem Cell 22:653-667.e5
Albright, Emily L; Schroeder, Mary C; Foster, Kendra et al. (2018) Nipple-Sparing Mastectomy is Not Associated with a Delay of Adjuvant Treatment. Ann Surg Oncol 25:1928-1935
Hu, G; Dasari, S; Asmann, Y W et al. (2018) Targetable fusions of the FRK tyrosine kinase in ALK-negative anaplastic large cell lymphoma. Leukemia 32:565-569
Link, Brian K (2018) Transformation of follicular lymphoma - Why does it happen and can it be prevented? Best Pract Res Clin Haematol 31:49-56
Guy, Christopher L; Weiss, Elisabeth; Christensen, Gary E et al. (2018) CALIPER: A deformable image registration algorithm for large geometric changes during radiotherapy for locally advanced non-small cell lung cancer. Med Phys 45:2498-2508
Scott, Aaron T; Howe, James R (2018) Management of Small Bowel Neuroendocrine Tumors. J Oncol Pract 14:471-482
Pelletier, Daniel J; Czeczok, Thomas W; Bellizzi, Andrew M (2018) A monoclonal antibody against SV40 large T antigen (PAb416) does not label Merkel cell carcinoma. Histopathology 73:162-166
Brooks, John M; Chapman, Cole G; Schroeder, Mary C (2018) Understanding Treatment Effect Estimates When Treatment Effects Are Heterogeneous for More Than One Outcome. Appl Health Econ Health Policy 16:381-393
Li, Fengyin; Zeng, Zhouhao; Xing, Shaojun et al. (2018) Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Nat Commun 9:5452

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