Abstract

: A critical enhancement to the Core Center for Systems Biology and Cancer at the Cancer Institute of New Jersey funded by this proposal will be a New Investigator who is an experimentalist with experience in uncovering the biological consequences of genetic mutations and single nucleotide polymorphisms in cancers. The individual will have knowledge and skills in molecular biology, genetics and cancer biology. The selected researcher will have an excellent publication record showing both productivity and originality in research directions. With this funding mechanism. The Cancer Institute of New Jersey shall recruit a New Investigator to complement and expand the breadth of existing institutional strengths add strength in scientific capacity to the Core Center.

Public Health Relevance

This funding will provide a promising early stage investigator with the research laboratory infrastructure, mentoring and oversight to accelerate translational cancer research and augment the breadth and capacity of The Cancer Institute of New Jersey's multidisciplinary community of researchers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA147892-02
Application #
7944173
Study Section
Special Emphasis Panel (ZCA1-PCRB-G (O9))
Program Officer
Perkins, Susan N
Project Start
2009-09-30
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2012-08-31
Support Year
2
Fiscal Year
2010
Total Cost
$717,681
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Pediatrics
Type
Schools of Medicine
DUNS #
617022384
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Feng, Zhaohui; Liu, Lianxin; Zhang, Cen et al. (2012) Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A 109:7013-8
Liu, Juan; Lin, Meihua; Zhang, Cen et al. (2012) TAp63? enhances nucleotide excision repair through transcriptional regulation of DNA repair genes. DNA Repair (Amst) 11:167-76
Feng, Zhaohui; Zhang, Cen; Kang, Hey-Joo et al. (2011) Regulation of female reproduction by p53 and its family members. FASEB J 25:2245-55
Zhang, Cen; Lin, Meihua; Wu, Rui et al. (2011) Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. Proc Natl Acad Sci U S A 108:16259-64
Hu, Wenwei; Zheng, Tongsen; Wang, Jiabei (2011) Regulation of Fertility by the p53 Family Members. Genes Cancer 2:420-30
Feng, Zhaohui; Zhang, Cen; Wu, Rui et al. (2011) Tumor suppressor p53 meets microRNAs. J Mol Cell Biol 3:44-50
Hu, Wenwei; Feng, Zhaohui; Modica, Ippolito et al. (2010) Gene Amplifications in Well-Differentiated Pancreatic Neuroendocrine Tumors Inactivate the p53 Pathway. Genes Cancer 1:360-368