Many Monell scientists conduct studies with animals and need to characterize their chemosensory phenotypes. They will benefit from the Phenotyping Core in the following ways. 1) This Core will provide a centralized resource of equipment and supplies that will receive dedicated support and regular maintenance. The Core will also centralize labor-intensive tasks, such as making equipment for preference tests. Studies will be designed and/or conducted by Core personnel with specialized expertise in phenotyping techniques. This will be more efficient than replicating these techniques and personnel in individual laboratories. Regular use and service will ensure that equipment is always operational and available for experimentation. 2) The Core will provide access to equipment and facilities (e.g., LabMaster, surgical facility) that are not practical to maintain in individual laboratories. The Core will offer a range of services and experimental designs that are not available in individual laboratories. 3) Scientists with no experience in animal phenotyping will receive training and will have access to equipment and expertise of the Core. This will facilitate their research and help them to collect preliminary data for grant applications. 4) This Research Core will be an integral component of the Core Center. Interactions between the Phenotyping Core and other Research Cores will facilitate collaborative and interdisciplinary studies that are often not feasible for individual laboratories. For example, the Phenotyping and Histology Cores will be used to characterize genetically engineered mice generated from constructs produced using the Molecular Biology Core. In forward genetics studies, the same animals will be examined using the Phenotyping and Genotyping Cores, and the data obtained will be used for chromosomal mapping studies. We estimate that 9 of the 13 R01 grants in our Research Base will use services provided by this Core at moderate to extensive levels. We also expect that 11 current faculty research groups at Monell will use the services provided by this Core. As a result, the Phenotyping Core will improve the efficiency and quality of animal model studies at the Center, accelerate existing NIDCD-funded projects, and advance translation of the results into benefits for public health.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Center Core Grants (P30)
Project #
5P30DC011735-03
Application #
8640719
Study Section
Special Emphasis Panel (ZDC1-SRB-Q)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$128,944
Indirect Cost
$36,923
Name
Monell Chemical Senses Center
Department
Type
DUNS #
088812565
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Freund, Jenna R; Mansfield, Corrine J; Doghramji, Laurel J et al. (2018) Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling. J Biol Chem 293:9824-9840
Feng, Pu; Chai, Jinghua; Yi, Huilan et al. (2018) Aggravated gut inflammation in mice lacking the taste signaling protein ?-gustducin. Brain Behav Immun 71:23-27
Qin, Yumei; Sukumaran, Sunil K; Jyotaki, Masafumi et al. (2018) Gli3 is a negative regulator of Tas1r3-expressing taste cells. PLoS Genet 14:e1007058
Lei, Weiwei; Ren, Wenwen; Ohmoto, Makoto et al. (2018) Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc Natl Acad Sci U S A 115:5552-5557
Chang, Eugene H; Willis, Amanda L; McCrary, Hilary C et al. (2017) Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis. J Allergy Clin Immunol 139:1990-1992.e2
Sukumaran, Sunil K; Lewandowski, Brian C; Qin, Yumei et al. (2017) Whole transcriptome profiling of taste bud cells. Sci Rep 7:7595
Lipchock, Sarah V; Spielman, Andrew I; Mennella, Julie A et al. (2017) Caffeine Bitterness is Related to Daily Caffeine Intake and Bitter Receptor mRNA Abundance in Human Taste Tissue. Perception 46:245-256
Hariri, Benjamin M; McMahon, Derek B; Chen, Bei et al. (2017) Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor. J Biol Chem 292:8484-8497
Tordoff, Michael G; Pearson, Jordan A; Ellis, Hillary T et al. (2017) Does eating good-tasting food influence body weight? Physiol Behav 170:27-31
Tomassini Barbarossa, Iole; Ozdener, M Hakan; Melania et al. (2017) Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people. Behav Brain Res 329:200-204

Showing the most recent 10 out of 83 publications