The overall objective of the Cell Function Analysis Core at the University of Washington Diabetes Research Center is to provide affiliates with analyses of glucose metabolism, mitochondrial function and intracellular signaling components critically important in diabetes, obesity and related disorders. To achieve this goal, the Core aims to: (1) Provide real time functional analysis in flow culture systems of tissues and cell types important in diabetes research. These have been expanded from just islets, to include retina, skeletal muscle, stem cells, macrophages, lymphocytes, adipocytes, endothelial cells, neuronal cells and hepatocytes;(2) Provide static assessment of cellular metabolism and function;(3) Isolate and culture primary tissue from rodents including islets and islet cells for subsequent morphological and functional characterization. Further, to procure human and monkey islets for the same purposes;and (4) Offer training and consultation to affiliates, their trainees and staff as well as develop new analytical tools requested by affiliates to support their studies of the metabolic regulation of cell function. The expansion of services provided during the current funding cycle has allowed the Core to better serve the needs of the Center's research base. As diabetes perturbs cellular metabolism and signaling in a variety of;cell types, the services of the Cell Function Analysis Core are, and will continue to be, of great value to Diabetes Research Center affiliate investigators who wish to study these aspects in order to gain a better understanding of physiology and disease pathophysiology.
The Cell Function Analysis Core provides measurements of cell metabolism, function and signaling in a number of different cell types in order to better understand their role in the pathogenesis of diabetes, obesity and related disorders.
|Auerbach, Brandon J; Dibey, Sepideh; Vallila-Buchman, Petra et al. (2018) Review of 100% Fruit Juice and Chronic Health Conditions: Implications for Sugar-Sweetened Beverage Policy. Adv Nutr 9:78-85|
|Wang, Yang; Sosinowski, Tomasz; Novikov, Andrey et al. (2018) C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes. Proc Natl Acad Sci U S A 115:162-167|
|Kikuchi, Shinsuke; Chen, Lihua; Xiong, Kevin et al. (2018) Smooth muscle cells of human veins show an increased response to injury at valve sites. J Vasc Surg 67:1556-1570.e9|
|Erickson, Michelle A; Banks, William A (2018) Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions. Pharmacol Rev 70:278-314|
|Parilla, Jacqueline H; Hull, Rebecca L; Zraika, Sakeneh (2018) Neprilysin Deficiency Is Associated With Expansion of Islet ?-Cell Mass in High Fat-Fed Mice. J Histochem Cytochem 66:523-530|
|Writing Group for the TRIGR Study Group; Knip, Mikael; Åkerblom, Hans K et al. (2018) Effect of Hydrolyzed Infant Formula vs Conventional Formula on Risk of Type 1 Diabetes: The TRIGR Randomized Clinical Trial. JAMA 319:38-48|
|Solan, Joell L; Lampe, Paul D (2018) Spatio-temporal regulation of connexin43 phosphorylation and gap junction dynamics. Biochim Biophys Acta Biomembr 1860:83-90|
|Howard, Barbara V; Aragaki, Aaron K; Tinker, Lesley F et al. (2018) A Low-Fat Dietary Pattern and Diabetes: A Secondary Analysis From the Women's Health Initiative Dietary Modification Trial. Diabetes Care 41:680-687|
|RISE Consortium (2018) Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test. Diabetes Care 41:1707-1716|
|Norris, Jill M; Lee, Hye-Seung; Frederiksen, Brittni et al. (2018) Plasma 25-Hydroxyvitamin D Concentration and Risk of Islet Autoimmunity. Diabetes 67:146-154|
Showing the most recent 10 out of 1296 publications