RADIOIMMUNOASSAY/BIOMARKERS CORE: Director- M. Reilly The RIA/Biomarkers Core supports the overall mission of the Penn Diabetes Research Center (DRC) to prevent, treat, and cure diabetes mellitus by providing an assay service that has proven essential for diabetes-related research in the DRC. Under the leadership of Drs. Muredach Reilly and Heather Collins, the Core has evolved from a facility that used to be focused mainly on rat and human Insulin, glucagon and C-peptide to a diverse, high-volume and cost-effective service. 100 different diabetes and endocrinology-related markers can be assayed. We believe that performing a large number of radioimmuno-assays and ELISAs in a central core facility rather than in scattered locations throughout the University represents a significant overall savings in equipment and also provides results with better quality. The increase in assays reflects the expansion of diabetes research into the areas of gut hormones, inflammation and obesity and the increased interest in metabolism by the Penn scientific community. Parallel to this increase in assays, the Core has also experienced more investigators using its services. We utilize a charge-back system to recover the cost of the assays and our charges vary from $1.25 to $8 per sample, which are among the lowest of all DRC. The Vision for the RIA/Biomarkers is consolidation and expansion of services through integration with other NIH-cores at Penn, development of new services while enhancing overall quality, and reaching out to a greater number of Penn and Philadelphia diabetes and obesity research investigators. Thus, RIA/Biomarkers Core is a valuable and integral part of the future operation and development of the Penn DRC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK019525-38
Application #
8638932
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
38
Fiscal Year
2014
Total Cost
$252,843
Indirect Cost
$96,280
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Huang, Chen; Walker, Emily M; Dadi, Prasanna K et al. (2018) Synaptotagmin 4 Regulates Pancreatic ? Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev Cell 45:347-361.e5
Moreira, Leticia; Bakir, Basil; Chatterji, Priya et al. (2018) Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 5:289-298
Pei, Liming; Wallace, Douglas C (2018) Mitochondrial Etiology of Neuropsychiatric Disorders. Biol Psychiatry 83:722-730
Brown, Justin C; Rickels, Michael R; Troxel, Andrea B et al. (2018) Dose-response effects of exercise on insulin among colon cancer survivors. Endocr Relat Cancer 25:11-19
Rickels, M R; Markmann, E; Naji, A (2018) Successful pregnancies after islet transplantation for type 1 diabetes. Am J Transplant :
Friedman, Elliot S; Li, Yun; Shen, Ting-Chin David et al. (2018) FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. Gastroenterology 155:1741-1752.e5
Rickels, Michael R; DuBose, Stephanie N; Toschi, Elena et al. (2018) Mini-Dose Glucagon as a Novel Approach to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes. Diabetes Care 41:1909-1916
Jang, Cholsoon; Hui, Sheng; Lu, Wenyun et al. (2018) The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab 27:351-361.e3
Juliana, Christine A; Yang, Juxiang; Cannon, Corey E et al. (2018) A PDX1-ATF transcriptional complex governs ? cell survival during stress. Mol Metab 17:39-48
McKee, Sarah E; Zhang, Sisi; Chen, Li et al. (2018) Perinatal high fat diet and early life methyl donor supplementation alter one carbon metabolism and DNA methylation in the brain. J Neurochem 145:362-373

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