The mission of the Pilot and Feasibility (P&F) Program of the Penn DRC is to foster the development of new investigators and to provide seed support for innovative high-risk diabetes related projects, with an increasing emphasis on clinical and translational science. Over the past 2 funding periods (10 years), the Pilot and Feasibility Program has been highly successful in this regard. 46 investigators received P&F awards and, of these, 83% have garnered independent NIH support, the majority as R01s directly related to their P&F awards. During the previous funding period 28 traditional P&F grants were awarded among 89 applications submitted by investigators representing 27 Departments spanning multiple Schools and Institutes on the campus of the University of Pennsylvania as well as other Philadelphia Institutions. Of the funded grants, 80% were to new investigators and more than 15% were dedicated to clinical and translational projects. During the next funding period we propose to continue this core mission of the Pilot and Feasibility Program. Given the past successes of the program, the increasing cost of performing research in the setting of an ever more competitive general funding environment, and the clear need based on the steady influx of applications from both within and outside the diabetes research community, it is critical to continue the mission of the P&F Program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK019525-41
Application #
9322082
Study Section
Special Emphasis Panel (ZDK1-GRB-S (J1)P)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
41
Fiscal Year
2017
Total Cost
$341,821
Indirect Cost
$113,804
Name
University of Pennsylvania
Department
Type
Domestic Higher Education
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Pickett-Blakely, Octavia; Young, Kimberly; Carr, Rotonya M (2018) Micronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis. Cell Mol Gastroenterol Hepatol 6:451-462
Kameswaran, Vasumathi; Golson, Maria L; Ramos-Rodríguez, Mireia et al. (2018) The Dysregulation of the DLK1-MEG3 Locus in Islets From Patients With Type 2 Diabetes Is Mimicked by Targeted Epimutation of Its Promoter With TALE-DNMT Constructs. Diabetes 67:1807-1815
Huang, Chen; Walker, Emily M; Dadi, Prasanna K et al. (2018) Synaptotagmin 4 Regulates Pancreatic ? Cell Maturation by Modulating the Ca2+ Sensitivity of Insulin Secretion Vesicles. Dev Cell 45:347-361.e5
Moreira, Leticia; Bakir, Basil; Chatterji, Priya et al. (2018) Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer. Cell Mol Gastroenterol Hepatol 5:289-298
Pei, Liming; Wallace, Douglas C (2018) Mitochondrial Etiology of Neuropsychiatric Disorders. Biol Psychiatry 83:722-730
Brown, Justin C; Rickels, Michael R; Troxel, Andrea B et al. (2018) Dose-response effects of exercise on insulin among colon cancer survivors. Endocr Relat Cancer 25:11-19
Rickels, M R; Markmann, E; Naji, A (2018) Successful pregnancies after islet transplantation for type 1 diabetes. Am J Transplant :
Friedman, Elliot S; Li, Yun; Shen, Ting-Chin David et al. (2018) FXR-Dependent Modulation of the Human Small Intestinal Microbiome by the Bile Acid Derivative Obeticholic Acid. Gastroenterology 155:1741-1752.e5
Rickels, Michael R; DuBose, Stephanie N; Toschi, Elena et al. (2018) Mini-Dose Glucagon as a Novel Approach to Prevent Exercise-Induced Hypoglycemia in Type 1 Diabetes. Diabetes Care 41:1909-1916
Jang, Cholsoon; Hui, Sheng; Lu, Wenyun et al. (2018) The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids. Cell Metab 27:351-361.e3

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