The mission of the Washington University School of Medicine (WUMS) Diabetes Research Center (DRC) is to support and enhance research in diabetes and related metabolic diseases through Biomedical Research Core services reflecting the evolving needs of diabetes investigators, a vibrant Pilot &Feasibility Program and a dynamic Enrichment Program. Now in Its 35th year of continuous NIDDK funding, this DRC is located at an outstanding research institution with a longstanding tradition of excellence in diabetes investigation. The WUMS DRC Research Base is organized in three Focus Groups: Metabolic Regulation, Complications, and Islet Biology &Immunology. Investigators from each of these groups participate in DRC programs that address two central, interacting scientific themes-a) Approaches Across the Translational Spectrum, and b) Prevention of Diabetes Complications. Evidence that the WUMS DRC continues to successfully pursue the mission outlined in this renewal application Includes a record of outstanding productivity reflected by publications and peer-reviewed funding in diabetes and related research. Our research strategy will build on these accomplishments by: 1. Creating an environment that supports important as well as innovative research In diabetes and related metabolic disorders; 2. Supporting cutting edge basic and clinical research related to etiology, pathogenesis, prevention and cure of diabetes; 3. Raising awareness and interest in fundamental and clinical diabetes research in addition to enhancing multldisciplinary approaches to diabetes and its complications;and 4. Translating new knowledge in diabetes to improved treatment of patients with diabetes.
Diabetes and related metabolic disorders of obesity, insulin resistance, and metabolic syndrome are complex, systemic diseases involving environmental arid genetic Influences. The infrastructure and support of the DRC, as well as the collaborative nature of the DRC, are designed to foster multldisciplinary approaches across the translational spectrum to achieve progress in understanding the pathophysiology of these disorders and to develop of new treatments, cures and preventive strategies.
|Rusconi, B; Jiang, X; Sidhu, R et al. (2018) Gut Sphingolipid Composition as a Prelude to Necrotizing Enterocolitis. Sci Rep 8:10984|
|Chen, Yana; McCommis, Kyle S; Ferguson, Daniel et al. (2018) Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid. Endocrinology 159:609-621|
|Zhang, Yan; Rohatgi, Nidhi; Veis, Deborah J et al. (2018) PGC1? Organizes the Osteoclast Cytoskeleton by Mitochondrial Biogenesis and Activation. J Bone Miner Res 33:1114-1125|
|Xu, Wei; Mukherjee, Sumit; Ning, Yu et al. (2018) Cyclopropane fatty acid synthesis affects cell shape and acid resistance in Leishmania mexicana. Int J Parasitol 48:245-256|
|Hughes, Jing W; Bao, Yicheng K; Salam, Maamoun et al. (2018) Late-Onset T1DM and Older Age Predict Risk of Additional Autoimmune Disease. Diabetes Care :|
|Zhang, Xiangyu; Evans, Trent D; Jeong, Se-Jin et al. (2018) Classical and alternative roles for autophagy in lipid metabolism. Curr Opin Lipidol 29:203-211|
|Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Disrupted cholesterol metabolism promotes age-related photoreceptor neurodegeneration. J Lipid Res 59:1414-1423|
|Ban, Norimitsu; Lee, Tae Jun; Sene, Abdoulaye et al. (2018) Impaired monocyte cholesterol clearance initiates age-related retinal degeneration and vision loss. JCI Insight 3:|
|Mayer, Allyson L; Zhang, Yiming; Feng, Emily H et al. (2018) Enhanced Hepatic PPAR? Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice. Endocrinology 159:2110-2126|
|Weber, Kassandra J; Sauer, Madeline; He, Li et al. (2018) PPAR? Deficiency Suppresses the Release of IL-1? and IL-1? in Macrophages via a Type 1 IFN-Dependent Mechanism. J Immunol 201:2054-2069|
Showing the most recent 10 out of 654 publications