Abstract

(Taken from the application) This is a new core. The rationale for the core is to contribute both a ready supply of specific viral vector reagents and the expertise needed to develop the vector technology to keep pace with the growing experience in gene delivery to target cells.
The specific aims are 1. To generate adenovirus (Ad), adeno-associated virus (AAV) and retroviral vectors carrying reporter and specific genes for the center members; 2. To prepare, stockpile and distribute viral vectors constructed at the UNC as well as obtain other published vectors of interest for production and distribution; and 3. To continue to develop new methods of production and purification (e.g.. Ad-free AAV) as well as novel vectors (non-human lentiviral) that will provide researchers with high quality and efficient delivery systems.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK034987-16S1
Application #
6464124
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
16
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Rolston, Vineet S; Boroujerdi, Laleh; Long, Millie D et al. (2018) The Influence of Hormonal Fluctuation on Inflammatory Bowel Disease Symptom Severity-A Cross-Sectional Cohort Study. Inflamm Bowel Dis 24:387-393
Eaton, Kathryn; Pirani, Ali; Snitkin, Evan S et al. (2018) Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota. Elife 7:
Dong, Jing; Levine, David M; Buas, Matthew F et al. (2018) Interactions Between Genetic Variants and Environmental Factors Affect Risk of Esophageal Adenocarcinoma and Barrett's Esophagus. Clin Gastroenterol Hepatol 16:1598-1606.e4
Truax, Agnieszka D; Chen, Liang; Tam, Jason W et al. (2018) The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis. Cell Host Microbe 24:364-378.e6
Palacios, Michelle; Miner, Taryn A; Frederick, Daniel R et al. (2018) Identification of Two Regulators of Virulence That Are Conserved in Klebsiella pneumoniae Classical and Hypervirulent Strains. MBio 9:
Williamson, Ian A; Arnold, Jason W; Samsa, Leigh Ann et al. (2018) A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology. Cell Mol Gastroenterol Hepatol 6:301-319
Zhang, Cun-Jin; Wang, Chenhui; Jiang, Meiling et al. (2018) Act1 is a negative regulator in T and B cells via direct inhibition of STAT3. Nat Commun 9:2745
Evon, Donna M; Golin, Carol E; Ruffin, Rachel et al. (2018) Novel patient-reported outcomes (PROs) used in a pilot and feasibility study of a Cognitive Behavioral Coping Skills (CBCS) group intervention for patients with chronic hepatitis C. Pilot Feasibility Stud 4:92
Busch, Evan L; Don, Prabhani Kuruppumullage; Chu, Haitao et al. (2018) Diagnostic accuracy and prediction increment of markers of epithelial-mesenchymal transition to assess cancer cell detachment from primary tumors. BMC Cancer 18:82
Herfarth, Hans; Barnes, Edward L; Valentine, John F et al. (2018) Methotrexate Is Not Superior to Placebo in Maintaining Steroid-Free Response or Remission in Ulcerative Colitis. Gastroenterology 155:1098-1108.e9

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