The expanded Core moved in 2008 from Harborview Medical Center to the SLU campus. Services include: Energy Balance: Advantages of our new Sable System include that it can be used for either mice or rats, generates 4x more data per unit time, and reduces animal stress by employing cages that contain bedding (unlike other calorimeter systems) and thus more closely resemble the animal's home cage. This equipment has also overcome previous obstacles related to food intake measurement and has several additional advantages over other systems (e.g., pair-feeding capability, measurement of food preferences and the ability to conduct metabolic studies in a wide range of temperature environments). Metabolic Imaging Subcore: The overall goal is to assist NORC Als in harnessing advanced technologies that allow for in vivo assessment of metabolic phenotypes and endpoints in both animal and human models by capitalizing on existing state-of-the-art facilities, equipment, and expertise. Although some of these imaging services can be obtained directly via the UW Department of Radiology, our Subcore markedly increases accessibility to while reducing costs to NORC Als for these services. Moreover, many imaging protocols described below were developed and validated by Subcore faculty specifically to meet the needs of NORC Als, and would not otherwise be available. Services components include consultative services for optimization of existing or new protocols, training, and ongoing technological support, effectively facilitating access for NORC Als to contact experts and supporting their ability to acquire and/or analyze imaging data on a fee-for-service basis. These goals are met by taking advantage of the substantial investment in sophisticated equipment and maintenance that exists within UW imaging facilities, under the direction of the UW Department of Radiology. Routine access to these services is limited by the need to independently generate and provide complete image acquisition protocols (which requires significant technological expertise, especially for MRI) and by the fact that once images are acquired, users are also responsible for image processing to measure their qualitative or quantitative radiologic outcomes. Moreover, existing facilities do not provide for animal handling, human subject safety screening, or administration of stimuli during fMRI. Lastly, we are pleased to offer funds to enable new imaging projects to be piloted at no charge to the investigator. By providing these services as well as consultation to Als, the Metabolic Imaging Subcore facilitates access to and use of available advanced imaging technologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK035816-26
Application #
8390327
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (M3))
Project Start
Project End
Budget Start
2012-07-20
Budget End
2013-06-30
Support Year
26
Fiscal Year
2012
Total Cost
$345,903
Indirect Cost
$126,916
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Deem, Jennifer D; Muta, Kenjiro; Ogimoto, Kayoko et al. (2018) Leptin regulation of core body temperature involves mechanisms independent of the thyroid axis. Am J Physiol Endocrinol Metab 315:E552-E564
Freeman, Sara M; Ngo, Julie; Singh, Bhavdeep et al. (2018) Effects of Chronic Oxytocin Administration and Diet Composition on Oxytocin and Vasopressin 1a Receptor Binding in the Rat Brain. Neuroscience 392:241-251
Berkseth, Kathryn E; Rubinow, Katya B; Melhorn, Susan J et al. (2018) Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men. Obesity (Silver Spring) 26:1898-1904
Melhorn, Susan J; Askren, Mary K; Chung, Wendy K et al. (2018) FTO genotype impacts food intake and corticolimbic activation. Am J Clin Nutr 107:145-154
Ginos, Bigina N R; Navarro, Sandi L; Schwarz, Yvonne et al. (2018) Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding stud Metabolism 83:197-204
Shao, Dan; Villet, Outi; Zhang, Zhen et al. (2018) Glucose promotes cell growth by suppressing branched-chain amino acid degradation. Nat Commun 9:2935
Rubinow, Katya B; Houston, Barbara; Wang, Shari et al. (2018) Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian J Androl 20:276-283
den Hartigh, Laura J; Gao, Zhan; Goodspeed, Leela et al. (2018) Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota. J Nutr 148:562-572
Selamet, Umut; Katz, Ronit; Ginsberg, Charles et al. (2018) Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition Study. Am J Kidney Dis 72:419-428
Wright, Davene R; Christakis, Dimitri A; Lozano, Paula et al. (2018) Healthy, Wealthy, and Wise? Exploring Parent Comparative Optimism About Future Child Outcomes. MDM Policy Pract 3:2381468318774776

Showing the most recent 10 out of 601 publications