The Analytic Core is directed by Andrew Hoofnagle with Dan Raftery as the Associate Core Director and Director of the Discovery Metabolomics Subcore. The primary function of this Core is to provide Affiliate Investigators (AIs) with cutting-edge analytic assays that support the basic and clinical research needs of the community served by the NORC.
The Specific Aims for the Analytic Core and the Discovery Metabolomics Subcore are:
Specific Aim 1 : To provide access to high-quality, cost-effective laboratory testing for AIs.
Specific Aim 2 : To respond to AI needs for the development, validation, and optimization of laboratory tests used in nutrition and obesity research involving human and animal specimens.
Specific Aim 3 : To work with AIs to optimize specimen collection and storage as well as assay platforms and workflows. Comprehensive, state-of-the-art services are provided by the Core in a highly cost-effective fashion both by developing specialized tests specifically for AIs (direct services) and by serving as a conduit for AIs to access laboratory services offered elsewhere at the University of Washington (UW) (indirect services). By handling logistics for referrals to clinical laboratories throughout the UW system, the Core seamlessly provides services that are broader in scope than would otherwise be available in a manner that is much more cost-effective than would be possible if the Analytic Core operated as an isolated unit that performs only direct testing. To meet the need for laboratory testing requested by AIs, we respond to direct requests for assays while also anticipating future needs and research directions by actively helping AIs to shape decisions related to study design and methodology and by developing new assays, incorporating new technologies, and performing the developmental research needed to establish and/or facilitate access to analyses.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK035816-31A1
Application #
10045743
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
31
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Berkseth, Kathryn E; Rubinow, Katya B; Melhorn, Susan J et al. (2018) Hypothalamic Gliosis by MRI and Visceral Fat Mass Negatively Correlate with Plasma Testosterone Concentrations in Healthy Men. Obesity (Silver Spring) 26:1898-1904
Melhorn, Susan J; Askren, Mary K; Chung, Wendy K et al. (2018) FTO genotype impacts food intake and corticolimbic activation. Am J Clin Nutr 107:145-154
Ginos, Bigina N R; Navarro, Sandi L; Schwarz, Yvonne et al. (2018) Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding stud Metabolism 83:197-204
Shao, Dan; Villet, Outi; Zhang, Zhen et al. (2018) Glucose promotes cell growth by suppressing branched-chain amino acid degradation. Nat Commun 9:2935
Rubinow, Katya B; Houston, Barbara; Wang, Shari et al. (2018) Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice. Asian J Androl 20:276-283
den Hartigh, Laura J; Gao, Zhan; Goodspeed, Leela et al. (2018) Obese Mice Losing Weight Due to trans-10,cis-12 Conjugated Linoleic Acid Supplementation or Food Restriction Harbor Distinct Gut Microbiota. J Nutr 148:562-572
Selamet, Umut; Katz, Ronit; Ginsberg, Charles et al. (2018) Serum Calcitriol Concentrations and Kidney Function Decline, Heart Failure, and Mortality in Elderly Community-Living Adults: The Health, Aging, and Body Composition Study. Am J Kidney Dis 72:419-428
Wright, Davene R; Christakis, Dimitri A; Lozano, Paula et al. (2018) Healthy, Wealthy, and Wise? Exploring Parent Comparative Optimism About Future Child Outcomes. MDM Policy Pract 3:2381468318774776
Meek, Thomas H; Matsen, Miles E; Faber, Chelsea L et al. (2018) In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus. Endocrinology 159:1585-1594
Du, Dan; Gu, Haiwei; Djukovic, Danijel et al. (2018) Multiplatform Metabolomics Investigation of Antiadipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid. J Proteome Res 17:2092-2101

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