The main objective of the Boston University Pilot and Feasibility (P&F) Program is to catalyze transformative advances in both translational and basic diabetes research, expanding and broadening the innovative parent Joslin P&F program. The new program would be integrated into the parent Joslin P&F program and will adopt its administrative and scientific policies and infrastructure. The program will have two main components: a regional Computational Systems Biology program and a Boston University Medical Center based new investigator program. The majority of the researchers enrolled in the new Computational Systems Biology program are either new or well-established systems biology researchers at BU, MIT or Harvard with limited prior research in diabetes or metabolic diseases. Thus, the scientific benefits from this program are expected to be high since these researchers bring a substantial prior track record in systems biology or network research successfully applied in other biomedical areas, but they have not previously worked in the biology, genetics or translational aspects of diabetes. The BU Medical Center program will emphasize funding new investigators who work in areas complementary to the focus areas of the Joslin primary P&F program and will include cardiovascular complications related to diabetes and obesity.

Public Health Relevance

The new Pilot and Feasibility Grant Program at Boston University provides seed grants to attract new researchers to the diabetes field. It specifically funds 1. New investigators in the diabetes field who have not previously received substantial NIH funding;2. Experienced investigators in the diabetes field who wish to strike out in a novel direction;and 3. Investigators from other fields embarking on a diabetes-related project for the first time.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK036836-27
Application #
8545776
Study Section
Special Emphasis Panel (ZDK1-GRB-S)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
27
Fiscal Year
2013
Total Cost
$260,728
Indirect Cost
$59,287
Name
Joslin Diabetes Center
Department
Type
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215
Rezanejad, Habib; Ouziel-Yahalom, Limor; Keyzer, Charlotte A et al. (2018) Heterogeneity of SOX9 and HNF1? in Pancreatic Ducts Is Dynamic. Stem Cell Reports 10:725-738
Katz, Michelle L; Guo, Zijing; Cheema, Alina et al. (2018) Management of Cardiovascular Disease Risk in Teens with Type 1 Diabetes: Perspectives of Teens With and Without Dyslipidemia and Parents. Pediatr Diabetes :
Gordin, Daniel; Harjutsalo, Valma; Tinsley, Liane et al. (2018) Differential Association of Microvascular Attributions With Cardiovascular Disease in Patients With Long Duration of Type 1 Diabetes. Diabetes Care 41:815-822
Teló, G H; Dougher, C E; Volkening, L K et al. (2018) Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes. Diabet Med 35:1355-1363
Srinivasan, Shylaja; Kaur, Varinderpal; Chamarthi, Bindu et al. (2018) TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care 41:554-561
Goldford, Joshua E; Lu, Nanxi; Baji?, Djordje et al. (2018) Emergent simplicity in microbial community assembly. Science 361:469-474
Soto, Marion; Orliaguet, Lucie; Reyzer, Michelle L et al. (2018) Pyruvate induces torpor in obese mice. Proc Natl Acad Sci U S A 115:810-815
Karst, Sonja G; Lammer, Jan; Radwan, Salma H et al. (2018) Characterization of In Vivo Retinal Lesions of Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy. Int J Endocrinol 2018:7492946
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Kim, Youngjo; Bayona, Princess Wendy; Kim, Miri et al. (2018) Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance. Front Immunol 9:696

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