Since the founding of CURE by Dr. Morton I. Grosssman in 1973, a strong tradition of expertise has existed for exploring the physiological mechanisms involved in the regulation of GI function under normal and pathological conditions, as recently reviewed by the Animal Models Core Co-Director (1). In the past two decades, tremendous increases in knowledge derived from cell and molecular biological approaches have driven interest to evaluate in vitro findings within the context of integrative physiological models. Conversely, observations derived from the role of specific endogenous hormones or transmitters in the regulation of normal or abnormal GI functions in in vivo models have provided the impetus for focused mechanistic evaluation at the cellular level using molecular biological methods. Indeed, a common theme in many of the research programs of the Center investigators is the elucidation of the pathophysiological role and molecular mechanism of action of gastrointestinal peptide hormones, neuropeptides, paracrine regulators and classical neurotransmitters. Thus, in vivo studies are important for the implementation of many research programs of CURE: DDRCC members to: 1. Assess the biological significance of mechanisms elucidated in vitro; 2. Dissect the neural, hormonal and paracrine mechanisms involved in integrated physiological regulation of GI function; 3. Test biological activity of new reagents (i.e., antibodies, selective receptor agonists or antagonists or novel peptides); 4. Establish relevant models of GI diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK041301-23
Application #
8374971
Study Section
Special Emphasis Panel (ZDK1-GRB-8)
Project Start
Project End
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
23
Fiscal Year
2012
Total Cost
$114,625
Indirect Cost
$23,653
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kaji, I; Akiba, Y; Furuyama, T et al. (2018) Free fatty acid receptor 3 activation suppresses neurogenic motility in rat proximal colon. Neurogastroenterol Motil 30:
Kim, Paul H; Luu, Jennings; Heizer, Patrick et al. (2018) Disrupting the LINC complex in smooth muscle cells reduces aortic disease in a mouse model of Hutchinson-Gilford progeria syndrome. Sci Transl Med 10:
Dong, Tien S; Aby, Elizabeth S; Benhammou, Jihane N et al. (2018) Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c. World J Hepatol 10:612-621
Videlock, Elizabeth J; Mahurkar-Joshi, Swapna; Hoffman, Jill M et al. (2018) Sigmoid colon mucosal gene expression supports alterations of neuronal signaling in irritable bowel syndrome with constipation. Am J Physiol Gastrointest Liver Physiol 315:G140-G157
Chen, Natalie Y; Kim, Paul; Weston, Thomas A et al. (2018) Fibroblasts lacking nuclear lamins do not have nuclear blebs or protrusions but nevertheless have frequent nuclear membrane ruptures. Proc Natl Acad Sci U S A 115:10100-10105
Larauche, Muriel; Moussaoui, Nabila; Biraud, Mandy et al. (2018) Brain corticotropin-releasing factor signaling: Involvement in acute stress-induced visceral analgesia in male rats. Neurogastroenterol Motil :e13489
Zhou, Haoming; Wang, Han; Ni, Ming et al. (2018) Glycogen synthase kinase 3? promotes liver innate immune activation by restraining AMP-activated protein kinase activation. J Hepatol 69:99-109
Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Lin, De-Chen; Wang, Ming-Rong; Koeffler, H Phillip (2018) Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients. Gastroenterology 154:374-389
Bonfiglio, Ferdinando; Zheng, Tenghao; Garcia-Etxebarria, Koldo et al. (2018) Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome. Gastroenterology 155:168-179

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