This application is for a proposed Digestive Diseases Center at the University of Chicago. The proposed Center will be a multidisciplinary and cooperative endeavor involving over 30 investigators in the Departments of Medicine, Pediatrics, Biochem. & Molec. Biology, Pharm. Phys. Sci. and Pathology.
The aims of the Center are: 1) to foster digestive diseases- related research in a supportive, integrative, collaborative and multidisciplinary manner; 2) to enhance the basic research capabilities of established digestive diseases investigators; 3) to encourage investigators not involved in digestive diseases-related research to become interested in pursuing problems related to this important area of investigation; 4) to develop and implement programs for training and establishment of young investigators in digestive diseases-related research; 5) to eventually facilitate the transfer of new research findings to the clinical area; and 6) to inform others in both professional and lay settings of the accomplishments, opportunities and advances in digestive diseases-related research. This application contains proposals for five core laboratories (Cell Culture, Molecular Biology, Ultrastructure, Protein and Peptide Analysis, Biochemistry and Biophysics) to foster digestive diseases-related research, Pilot and Feasibility Studies and New Investigator Award programs to foster participation of younger and established investigators in research related to digestive diseases and an Administrative Core to oversee the operation of the proposed Center as a whole. Taken together, these objectives and components define the proposed University of Chicago Digestive Diseases Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
3P30DK042086-05S1
Application #
2142079
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1990-01-01
Project End
1995-12-31
Budget Start
1994-01-20
Budget End
1995-12-31
Support Year
5
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Samanta, Priyanka; Wang, Yitang; Fuladi, Shadi et al. (2018) Molecular determination of claudin-15 organization and channel selectivity. J Gen Physiol 150:949-968
McDonald, Daniel; Hyde, Embriette; Debelius, Justine W et al. (2018) American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems 3:
Martinez-Guryn, Kristina; Hubert, Nathaniel; Frazier, Katya et al. (2018) Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids. Cell Host Microbe 23:458-469.e5
McDonald, Benjamin D; Jabri, Bana; Bendelac, Albert (2018) Diverse developmental pathways of intestinal intraepithelial lymphocytes. Nat Rev Immunol 18:514-525
Pierre, Joseph F; Hinterleitner, Reinhard; Bouziat, Romain et al. (2018) Dietary antioxidant micronutrients alter mucosal inflammatory risk in a murine model of genetic and microbial susceptibility. J Nutr Biochem 54:95-104
Johnson, Carl D; Barlow-Anacker, Amanda J; Pierre, Joseph F et al. (2018) Deletion of choline acetyltransferase in enteric neurons results in postnatal intestinal dysmotility and dysbiosis. FASEB J 32:4744-4752
Williams Jr, James C; Borofsky, Michael S; Bledsoe, Sharon B et al. (2018) Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol 199:186-192
Micic, Dejan; Yarur, Andres; Gonsalves, Alex et al. (2018) Risk Factors for Clostridium difficile Isolation in Inflammatory Bowel Disease: A Prospective Study. Dig Dis Sci 63:1016-1024
Brown, Hailey M; Biering, Scott B; Zhu, Allen et al. (2018) Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays 40:e1700231
Lu, Lei; Claud, Erika C (2018) Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health. Curr Pathobiol Rep 6:15-21

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