application): The Metabolic Core Laboratory provides tools and expertise for the study of metabolic pathways involved in nutrient utilization. The study of metabolic pathways, and especially of insulin action, involves complex methodology, expensive equipment and specialized knowledge. Consolidation of these tools and techniques in a single laboratory has proven to be an accurate cost-effective means of meeting the needs of many members of the CNRU research base. The core was designed to be complementary to the other core laboratories, since investigators interested in nutrient utilization often combine services available through this core laboratory with services available through the Energy Balance and Mass Spectrometry Cores. For example, measurements of insulin sensitivity are frequently obtained in combination with measurements of body composition, energy expenditure and substrate turnover. The Metabolic Core Laboratory has been well-used by investigators in all 4 research focus areas. Although some CNRU investigators may still be performing some of the measurements offered by this core in their own laboratory, the establishment of shared techniques has gradually reduced redundancies and provided these services in a cost-effective manner. One of the goals of this, and other cores, is to provide services to allow investigators to extend their hypotheses beyond their current level of examination. The services of the Metabolic Core Laboratory have been used by many investigators to extend their research beyond the specific hypotheses proposed in their R01 grants. For example, many investigators who did not previously assess insulin action in their own studies have taken advantage of this core laboratory to obtain these measures using the minimum model technique.

Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Colorado Denver
United States
Zip Code
Kuwabara, Masanari; Hisatome, Ichiro; Roncal-Jimenez, Carlos A et al. (2018) Correction: Increased Serum Sodium and Serum Osmolarity Are Independent Risk Factors for Developing Chronic Kidney Disease; 5 Year Cohort Study. PLoS One 13:e0197941
Espeland, Mark A; Carmichael, Owen; Hayden, Kathleen et al. (2018) Long-term Impact of Weight Loss Intervention on Changes in Cognitive Function: Exploratory Analyses from the Action for Health in Diabetes Randomized Controlled Clinical Trial. J Gerontol A Biol Sci Med Sci 73:484-491
Gadek, Katherine E; Wang, Hong; Hall, Monica N et al. (2018) Striated muscle gene therapy for the treatment of lipoprotein lipase deficiency. PLoS One 13:e0190963
Foright, R M; Presby, D M; Sherk, V D et al. (2018) Is regular exercise an effective strategy for weight loss maintenance? Physiol Behav 188:86-93
Hurtado-Arestegui, Abdias; Plata-Cornejo, Raul; Cornejo, Arturo et al. (2018) Higher prevalence of unrecognized kidney disease at high altitude. J Nephrol 31:263-269
Musci, Robert V; Hamilton, Karyn L; Miller, Benjamin F (2018) Targeting mitochondrial function and proteostasis to mitigate dynapenia. Eur J Appl Physiol 118:1-9
Reusch, Jane E B; Kumar, T Rajendra; Regensteiner, Judith G et al. (2018) Identifying the Critical Gaps in Research on Sex Differences in Metabolism Across the Life Span. Endocrinology 159:9-19
Geng, Xin; Irvin, Marguerite R; Hidalgo, Bertha et al. (2018) An exome-wide sequencing study of lipid response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort. J Lipid Res 59:722-729
Schenkman, Margaret; Moore, Charity G; Kohrt, Wendy M et al. (2018) Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol 75:219-226
Stojanovi?, Danijela; B?žková, Petra; Mukamal, Kenneth J et al. (2018) Soluble Inflammatory Markers and Risk of Incident Fractures in Older Adults: The Cardiovascular Health Study. J Bone Miner Res 33:221-228

Showing the most recent 10 out of 756 publications