Abstract

The mission of the core is to provide analytical services and to develop new assays and technology to support CNRU investigators to develop an understanding of nutrient absorption, metabolism, and turnover. The Mass Spectrometry Core furnishes instruments and technologies that would not normally be available to most independent investigators and is, in fact, essential to the success of these investigators. The core is also developing diagnostic tools to predict disease and to monitor progress of disease and treatment. In addition, we provide comprehensive instruction for interested CNRU investigators in order to increase their proficiency in our highly complex technologies and instrumentation. The range of instrumentation available to CNRU investigators through the Core has significantly expanded during the last year and now includes GC-MS, isotope ratio MS, LC-MS, LC-MS/MS, LCMS/iontrap (with all components required for proteomics research), time-of-flight mass spectrometry, two-dimensional gel electrophoresis equipment and software, preparative HPLC with MS-guided automatic autosampler, 2 NMR spectrometers for biochemical profiling of cell and tissue metabolism (metabolomics) and animal MRI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK048520-15
Application #
7910647
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
15
Fiscal Year
2009
Total Cost
$416,634
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Millstein, Richard J; Pyle, Laura L; Bergman, Bryan C et al. (2018) Sex-specific differences in insulin resistance in type 1 diabetes: The CACTI cohort. J Diabetes Complications 32:418-423
Thompson, Tricia; Keller, Amy; Lyons, Trisha Bury (2018) When foods contain both a gluten-free claim and an allergen advisory statement for wheat: should consumers be concerned? Eur J Clin Nutr :
Faudzi, Farah Nadia M; Armitage, Christopher J; Bryant, Christina et al. (2018) Cultural Adaptations to the Measurement of Attitudes to Ageing: Psychometric Assessment of the Malay Reactions to Ageing Questionnaire. Assessment :1073191118766400
Hayden, Kathleen M; Baker, Laura D; Bray, George et al. (2018) Long-term impact of intensive lifestyle intervention on cognitive function assessed with the National Institutes of Health Toolbox: The Look AHEAD study. Alzheimers Dement (Amst) 10:41-48
Legget, Kristina T; Cornier, Marc-Andre; Bessesen, Daniel H et al. (2018) Greater Reward-Related Neuronal Response to Hedonic Foods in Women Compared with Men. Obesity (Silver Spring) 26:362-367
Ladd, Amy K; Skillman, Heather E; Haemer, Matthew A et al. (2018) Preventing Underfeeding and Overfeeding: A Clinician's Guide to the Acquisition and Implementation of Indirect Calorimetry. Nutr Clin Pract 33:198-205
Capobianco, Evangelina; Fornes, Daiana; Roberti, Sabrina Lorena et al. (2018) Supplementation with polyunsaturated fatty acids in pregnant rats with mild diabetes normalizes placental PPAR? and mTOR signaling in female offspring developing gestational diabetes. J Nutr Biochem 53:39-47
Houston, Denise K; Neiberg, Rebecca H; Miller, Michael E et al. (2018) Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study. J Gerontol A Biol Sci Med Sci 73:1552-1559
Kuwabara, Masanari; Hisatome, Ichiro; Niwa, Koichiro et al. (2018) Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension 71:78-86
Peppler, Willem T; Townsend, Logan K; Knuth, Carly M et al. (2018) Subcutaneous inguinal white adipose tissue is responsive to, but dispensable for, the metabolic health benefits of exercise. Am J Physiol Endocrinol Metab 314:E66-E77

Showing the most recent 10 out of 756 publications