Overall Component This is an application for a 5 year competitive renewal for the Colorado Nutrition Obesity Research Center (NORC). The broad goal of the NORC is to support and enhance ongoing nutrition/obesity research and to promote interdisciplinary collaborative, vertically integrated research among members of the Colorado NORC research base. We are now in our twentieth year of operation and the NORC supports over 96 regular and 16 mentored investigators in the research base who generate over $43,000,000 per year in direct costs for nutrition/obesity research. The resources of the NORC have been leveraged to secure over $70,000,000 (not counting individual research grants) in support for nutrition/obesity research at the University of Colorado. The research supported by the NORC ranges from cellular and molecular to clinical research to research in the community. We have made a commitment to foster team science within our research base because we believe this is the logical next step in the evolution of our NORC - to use NORC resources to create and support research teams to address big and important research questions that can best be addressed via an interdisciplinary, collaborative approach. We have organized our research base around 4 research team - 1) Maternal-Fetal Origins of Obesity; 2) Investigations in Metabolism, Aging, Gender, and Exercise (IMAGE); 3) Weight Management; 4) Obesity and Metabolic Dysregulation. These teams have already been successful in raising additional resources for team science. The research base is supported by 3 scientific cores that support basic, clinical and community researchers: 1) Molecular & Cellular Analytical; 2) Energy Balance Assessment; 3) Clinical Intervention and Translation. The Colorado NORC has strong leadership with Dr. James O. Hill continuing to serve as NORC Director and Drs. Dan Bessesen and Paul MacLean serving as Associate Directors. The Colorado NORC is located within the Anschutz Health and Wellness Center (AHWC) which is located within the University of Colorado, School of Medicine. A mission of the AHWC is to promote research translation and AHWC facilities provide an opportunity for translation of research emanating from the NORC. Our pilot and feasibility program has been extremely successful in helping develop our new investigators into independent researchers and national leaders in nutrition/obesity. Our enrichment program has been successful in helping promote collaboration and in enriching other health care professionals and the community in the areas of nutrition and obesity. In its twentieth year, the Colorado NORC is well recognized and well respected as one of the leading centers in the world for nutrition and obesity research and research translation.

Public Health Relevance

The Colorado NORC will promote interdisciplinary research in obesity and nutrition by supporting over 100 researchers who are working in this area. The NORC provides scientific core laboratories, a pilot and feasibility program and an enrichment program. Overall the impact of research being conducted by NORC researchers can have an impact on reducing rates of obesity.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK048520-21
Application #
8975476
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Evans, Mary
Project Start
1997-01-01
Project End
2020-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
21
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Erlandson, Kristine M; Lake, Jordan E; Sim, Myung et al. (2018) Bone Mineral Density Declines Twice as Quickly Among HIV-Infected Women Compared With Men. J Acquir Immune Defic Syndr 77:288-294
Kuwabara, Masanari; Hisatome, Ichiro; Niwa, Koichiro et al. (2018) Uric Acid Is a Strong Risk Marker for Developing Hypertension From Prehypertension: A 5-Year Japanese Cohort Study. Hypertension 71:78-86
Peppler, Willem T; Townsend, Logan K; Knuth, Carly M et al. (2018) Subcutaneous inguinal white adipose tissue is responsive to, but dispensable for, the metabolic health benefits of exercise. Am J Physiol Endocrinol Metab 314:E66-E77
Bellows, Laura L; McCloskey, Morgan; Clark, Lauren et al. (2018) HEROs: Design of a Mixed-Methods Formative Research Phase for an Ecocultural Intervention to Promote Healthy Eating and Activity Behaviors in Rural Families With Preschoolers. J Nutr Educ Behav :
Lake, Jordan E; Li, Xiuhong; Palella Jr, Frank J et al. (2018) Metabolic health across the BMI spectrum in HIV-infected and HIV-uninfected men. AIDS 32:49-57
Jovanovich, Anna; Isakova, Tamara; Block, Geoffrey et al. (2018) Deoxycholic Acid, a Metabolite of Circulating Bile Acids, and Coronary Artery Vascular Calcification in CKD. Am J Kidney Dis 71:27-34
Hill, James M; O'Leary, Joseph (2018) Generalized transformations and coordinates for static spherically symmetric general relativity. R Soc Open Sci 5:171109
Diab, Liliane; Krebs, Nancy F (2018) Vitamin Excess and Deficiency. Pediatr Rev 39:161-179
Bjornstad, Petter; Cree-Green, Melanie; Baumgartner, Amy et al. (2018) Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtform Pediatr Diabetes 19:436-442
Cintron, Dahima; Lahr, Brian D; Bailey, Kent R et al. (2018) Effects of oral versus transdermal menopausal hormone treatments on self-reported sleep domains and their association with vasomotor symptoms in recently menopausal women enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). Menopause 25:145-153

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