Overview of the Zebrafish System. The zebrafish is now established as a viable complement and alternative to rodents for modeling human development and disease. The Zebrafish core (CORE B) has led the way in generating and collecting a unique repository of zebrafish hematopoietic mutants available for distribution to the international scientific community. The Center had a leadership role in the Trans-NIH Zebrafish Genome Initiative. CORE B has advanced the zebrafish model system by developing new tools and technology, and provided these, and related resources, to researchers who use the fish to study hematopoiesis and other processes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK049216-19
Application #
8565740
Study Section
Special Emphasis Panel (ZDK1-GRB-G (O3))
Project Start
1997-09-05
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
19
Fiscal Year
2012
Total Cost
$329,552
Indirect Cost
$134,143
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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Mandelbaum, Joseph; Shestopalov, Ilya A; Henderson, Rachel E et al. (2018) Zebrafish blastomere screen identifies retinoic acid suppression of MYB in adenoid cystic carcinoma. J Exp Med 215:2673-2685
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Gansner, John M; Leung, Alexander D; Superdock, Michael et al. (2017) Sorting zebrafish thrombocyte lineage cells with a Cd41 monoclonal antibody enriches hematopoietic stem cell activity. Blood 129:1394-1397
Canver, Matthew C; Lessard, Samuel; Pinello, Luca et al. (2017) Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet 49:625-634

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