The Clinical Science Research Core (CSRC) enhances and facilitates nutrition/obesity-related clinical translational research by assisting investigators in conducting studies in human subjects through the operation of two sub-cores. The Clinical Studies Performance sub-core facilitates clinical research by assistance with: i) subject recruitment, ii) planning and performance of clinical studies, iii) collection of fat and muscle tissue samples, iv) exercise testing, v) lifestyle intervention, vi) whole-body and regional body composition assessments (DEXA, MRI, MRS), vii) indirect calorimetry, and viii) assessment of cardiovascular structure and function. The Metabolic Kinetics sub-core provides comprehensive state-of the- art stable isotope labeled tracer and non-tracer applications to study diverse areas of metabolic function (production/synthesis and catabolic rates;insulin sensitivity, beta-cell function). In addition, the CSRC provides training for investigators, their staff, and research fellows in these areas of clinical research, both in the form of one-on-one hands-on instruction as well as through seminars and lecture series. Combining these services within one Core provides a cohesive organizational structure that facilitates the performance of complex clinical research studies, fosters interdisciplinary collaborations between NORC investigators, and reduces the barriers for basic scientists and young investigators who wish to conduct clinical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056341-14
Application #
8640146
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
14
Fiscal Year
2014
Total Cost
$325,459
Indirect Cost
$111,341
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Yoshino, Jun; Baur, Joseph A; Imai, Shin-Ichiro (2018) NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab 27:513-528
Yoshino, Jun; Almeda-Valdes, Paloma; Moseley, Anna C et al. (2018) Percutaneous muscle biopsy-induced tissue injury causes local endoplasmic reticulum stress. Physiol Rep 6:e13679
Coggan, Andrew R; Broadstreet, Seth R; Mahmood, Kiran et al. (2018) Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction. J Card Fail 24:65-73
Yoshino, Jun (2018) The role of breakfast in adipose tissue biology. J Physiol 596:551-552
Acevedo, María Belén; Ferrando, Ramiro; Patterson, Bruce W et al. (2018) Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis :
Sun, Shishuo; Tan, Pengcheng; Huang, Xiaoheng et al. (2018) Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes. J Biol Chem 293:2383-2394
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Frolova, Antonina I; Wang, Judy J; Conner, Shayna N et al. (2018) Spontaneous Labor Onset and Outcomes in Obese Women at Term. Am J Perinatol 35:59-64
Shibao, Cyndya A; Celedonio, Jorge E; Tamboli, Robyn et al. (2018) CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels. J Clin Endocrinol Metab 103:1856-1866
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :

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