Adipose tissue function is central to overall metabolism. In addition to its energy storage role, adipose tissue secretes bioactive factors (i.e. adipokines) that contribute to regulating food intake, energy expenditure and normal functioning of key organs such as the vasculature, muscle and liver. Excessive expansion of adipose tissue, as occurs in obesity, is associated with cardiovascular abnormalities and systemic inflammation which ultimately may promote development of cardiovascular disease, diabetes and cancer. Adipose tissue expansion involves processes that include adipocyte hypertrophy, adipogenesis (pre-adipocyte differentiation), angiogenesis (new blood vessel formation) and extracellular matrix remodeling. There is growing interest in targeting these processes as a potentially efficient way to limit adipose tissue mass and obesity. In addition, understanding the molecular mechanisms that mediate lipid storage and the nutritional effects on adipose tissue metabolism are important in the pathophysiology of obesity. The Adipocyte Biology and Molecular Nutrition (ABMN) Core was established in 2006 and has since played a central role in facilitating molecular research related to nutrition and obesity by NORC investigators. The core provides NORC researchers, especially young investigators, access to specific equipment and expertise that are difficult to assemble by individual investigators and that can present a barrier to those new to this field. The state-of-the-art research infrastructure and training available through the ABMN Core facilitate and enhance nutrition/obesity related research and maximize resource use for NORC investigators, particularly young investigators who are establishing independent research programs. The core helps clinical investigators who are interested in the mechanisms underlying the pathophysiology associated with obesity in conducting molecular studies of biopsy samples obtained from metabolically phenotyped subjects. The ABMN core also creates opportunities for interactions and collaborations that often lead to initiation of new multidiscipiinary projects and help recruit basic and clinical investigators to nutrition/obesity related research (see publication record).

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK056341-14
Application #
8640151
Study Section
Special Emphasis Panel (ZDK1-GRB-2)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
14
Fiscal Year
2014
Total Cost
$106,669
Indirect Cost
$36,492
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Yoshino, Jun; Baur, Joseph A; Imai, Shin-Ichiro (2018) NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab 27:513-528
Yoshino, Jun; Almeda-Valdes, Paloma; Moseley, Anna C et al. (2018) Percutaneous muscle biopsy-induced tissue injury causes local endoplasmic reticulum stress. Physiol Rep 6:e13679
Coggan, Andrew R; Broadstreet, Seth R; Mahmood, Kiran et al. (2018) Dietary Nitrate Increases VO2peak and Performance but Does Not Alter Ventilation or Efficiency in Patients With Heart Failure With Reduced Ejection Fraction. J Card Fail 24:65-73
Yoshino, Jun (2018) The role of breakfast in adipose tissue biology. J Physiol 596:551-552
Acevedo, María Belén; Ferrando, Ramiro; Patterson, Bruce W et al. (2018) Effect of alcohol ingestion on plasma glucose kinetics after Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis :
Sun, Shishuo; Tan, Pengcheng; Huang, Xiaoheng et al. (2018) Ubiquitinated CD36 sustains insulin-stimulated Akt activation by stabilizing insulin receptor substrate 1 in myotubes. J Biol Chem 293:2383-2394
van Vliet, Stephan; Smith, Gordon I; Porter, Lane et al. (2018) The muscle anabolic effect of protein ingestion during a hyperinsulinaemic euglycaemic clamp in middle-aged women is not caused by leucine alone. J Physiol 596:4681-4692
Frolova, Antonina I; Wang, Judy J; Conner, Shayna N et al. (2018) Spontaneous Labor Onset and Outcomes in Obese Women at Term. Am J Perinatol 35:59-64
Shibao, Cyndya A; Celedonio, Jorge E; Tamboli, Robyn et al. (2018) CD36 Modulates Fasting and Preabsorptive Hormone and Bile Acid Levels. J Clin Endocrinol Metab 103:1856-1866
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :

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