Abstract

The Animal Models and Phenotyping Core will provide support for CNRU and other investigators in two major areas; the provision of new animal models through either transgenic or gene targeting techniques and the phenotypic characterization of animals for behavioral characteristics, body composition or metabolic parameters relevant to the overall goal of the CNRU in investigating the effects of nutritional programming on the development of obesity/diabetes. The Core will provide direct services and/or training for CNRU investigators and other faculty. The Core Director (David York) and Assoc. Director (Randy Mynatt) have long experience in animal physiology working with all the behavioral and metabolic phenotyping methods and the transgenic/gene targeting procedures that are included in this Core. Both user fees and institutional support will fund the Core. The Core staff will also work with faculty to develop additional established procedures or to develop new innovative methods that are relevant to the overall goal of the CNRU and that will enhance the productivity and research quality of the investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK072476-04
Application #
7669117
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
4
Fiscal Year
2008
Total Cost
$307,161
Indirect Cost

  Institution

Name
Lsu Pennington Biomedical Research Center
Department
Type
DUNS #
611012324
City
Baton Rouge
State
LA
Country
United States
Zip Code
70808

  Publications

Yan, Hao; Carmichael, Owen; Paul, Debashis et al. (2018) Estimating fiber orientation distribution from diffusion MRI with spherical needlets. Med Image Anal 46:57-72
Obanda, Diana; Page, Ryan; Guice, Justin et al. (2018) CD Obesity-Prone Rats, but not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight or Fat Accretion. Obesity (Silver Spring) 26:570-577
Wanders, Desiree; Forney, Laura A; Stone, Kirsten P et al. (2018) The Components of Age-Dependent Effects of Dietary Methionine Restriction on Energy Balance in Rats. Obesity (Silver Spring) 26:740-746
Trepanowski, John F; Kroeger, Cynthia M; Barnosky, Adrienne et al. (2018) Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: Secondary analysis of a randomized controlled trial. Clin Nutr 37:1871-1878
Staiano, Amanda E; Webster, Elizabeth Kipling; Allen, Andrew T et al. (2018) Screen-Time Policies and Practices in Early Care and Education Centers in Relationship to Child Physical Activity. Child Obes 14:341-348
Carmichael, Owen; Schwarz, Adam J; Chatham, Christopher H et al. (2018) The role of fMRI in drug development. Drug Discov Today 23:333-348
François, Marie; Qualls-Creekmore, Emily; Berthoud, Hans-Rudolf et al. (2018) Genetics-based manipulation of adipose tissue sympathetic innervation. Physiol Behav 190:21-27
Poret, J M; Souza-Smith, F; Marcell, S J et al. (2018) High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. Int J Obes (Lond) 42:535-541
Gautier, Jean-François; Fetita, Lila Sabrina; Riveline, Jean-Pierre et al. (2018) Sex Difference In the Effect of Fetal Exposure to Maternal Diabetes on Insulin Secretion. J Endocr Soc 2:391-397
Toledo, Frederico G S; Johannsen, Darcy L; Covington, Jeffrey D et al. (2018) Impact of prolonged overfeeding on skeletal muscle mitochondria in healthy individuals. Diabetologia 61:466-475

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