The Pilot Feasibility Studies Program, known as the O'Brien Fellows. Is designed as an efficient, effective and exciting framework in which Investigators new to the potential of fluorescence microscopy can begin to realize its transformational potential for their research. We propose a continuation of the O'Brien Fellows Program as the Pilot Feasibility Studies Program for the Center, replacing the conventional pilot grant program used In the original application and the last renewal of the Center. Up to 10 O'Brien Fellows will be selected In each of Years 1-5 of this award. Fellows will stay in Indianapolis in on-campus furnished apartments or local hotels for up to four weeks. The fellowship will help defray the cost of return travel to Indianapolis, apartment rental/hotel stay, supplies and consumables, animal procurement and housing and microscope time. Each fellow will be assigned to a liaison who is a senior investigator associated with the Center. The fellow will be provided with extensive training on the multiphoton microscope systems, and in other related techniques relevant to the proposed project

Public Health Relevance

By bringing O'Brien Fellows to work at the Center, we intend that they will have a critical mass of knowledge and experience that they can take back to their home Institutions and act as a catalyst for establishing these techniques there.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
5P30DK079312-07
Application #
8534769
Study Section
Special Emphasis Panel (ZDK1-GRB-6)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
7
Fiscal Year
2013
Total Cost
$165,875
Indirect Cost
$59,545
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Hato, Takashi; Winfree, Seth; Dagher, Pierre C (2018) Kidney Imaging: Intravital Microscopy. Methods Mol Biol 1763:129-136
Kolb, Alexander L; Corridon, Peter R; Zhang, Shijun et al. (2018) Exogenous Gene Transmission of Isocitrate Dehydrogenase 2 Mimics Ischemic Preconditioning Protection. J Am Soc Nephrol 29:1154-1164
Winfree, Seth; Dagher, Pierre C; Dunn, Kenneth W et al. (2018) Quantitative Large-Scale Three-Dimensional Imaging of Human Kidney Biopsies: A Bridge to Precision Medicine in Kidney Disease. Nephron 140:134-139
Dunn, Kenneth W; Sutton, Timothy A; Sandoval, Ruben M (2018) Live-Animal Imaging of Renal Function by Multiphoton Microscopy. Curr Protoc Cytom 83:12.9.1-12.9.25
Basile, D P; Collett, J A; Yoder, M C (2018) Endothelial colony-forming cells and pro-angiogenic cells: clarifying definitions and their potential role in mitigating acute kidney injury. Acta Physiol (Oxf) 222:
Swallow, E A; Aref, M W; Chen, N et al. (2018) Skeletal accumulation of fluorescently tagged zoledronate is higher in animals with early stage chronic kidney disease. Osteoporos Int 29:2139-2146
Micanovic, Radmila; Khan, Shehnaz; Janosevic, Danielle et al. (2018) Tamm-Horsfall Protein Regulates Mononuclear Phagocytes in the Kidney. J Am Soc Nephrol 29:841-856
Hato, Takashi; Zollman, Amy; Plotkin, Zoya et al. (2018) Endotoxin Preconditioning Reprograms S1 Tubules and Macrophages to Protect the Kidney. J Am Soc Nephrol 29:104-117
Dunn, Kenneth W; Ryan, Jennifer C (2017) Using quantitative intravital multiphoton microscopy to dissect hepatic transport in rats. Methods 128:40-51
Winfree, Seth; Hato, Takashi; Day, Richard N (2017) Intravital microscopy of biosensor activities and intrinsic metabolic states. Methods 128:95-104

Showing the most recent 10 out of 91 publications