(OVERALL CENTER) The mission of the Indiana Diabetes Research Center (IDRC) is to foster knowledge, support training, and promote basic and translational research in diabetes and related metabolic disorders, and their complications. A major focus of the IDRC has been the training and development of the ?next generation? of diabetes researcher. This focus has involved a state-wide effort led by the IDRC that has included resource provision (through the Research Cores), financial support and mentoring (through the Pilot and Feasibility Program and institutional funds), and creation of a collaborative diabetes ecosystem (through the Enrichment Program) for a burgeoning pool of investigators at Indiana University School of Medicine and its affiliated research institutions in Indiana (Purdue University, Indiana University-Purdue University in Indianapolis, Indiana University Bloomington, and the Indiana Biosciences Research Institute). The IDRC has been the catalyst for the growth of the Diabetes Research Base by 47% since the funding of this award in 2015. The IDRC consists of a Research Base of 94 highly collaborative investigators who represent 4 research themes: Cellular & Molecular Metabolism; Complications of Diabetes & Obesity; Islet Function & Survival; Nutrition & Physiology of Diabetes and Obesity. Collectively, this group of investigators brings in $46.7M in annual directs from the NIH, of which 50% ($23M) is from NIDDK. The research programs of these investigators is be augmented by 5 state-of-the- art Research Cores (Microscopy, Islet & Physiology, Translation, Swine, and Systems & Informatics Cores). An Enrichment Program, supported by 6 T32 training grants, will enhance learning and discovery. A Pilot and Feasibility Program will grow the Research Base by providing funding to highly promising young investigators. An Administrative Core will oversee governance of the IDRC, and will receive input from an Executive Committee, an Internal Advisory Board, and an External Advisory Board of world-renowned diabetes/metabolism research leaders.
The Aims of the IDRC will be to: (1) Promote high impact scientific discoveries by leveraging Research Cores that facilitate collaborations and the use of state-of-the-art methodologies and human studies in diabetes research; (2) Enhance a highly collaborative environment that promotes learning and encourages interaction among investigators; (3) Support the training and innovative research of a burgeoning pool of superb investigators with the potential to become future leaders in diabetes research; (4) Build and strengthen the diabetes research base, support infrastructure to ensure ongoing growth and innovation, and engage with the local community to raise diabetes awareness and involvement.

Public Health Relevance

It is estimated that nearly 10% of the US population has diabetes, and the percentage with obesity and pre- diabetes is alarmingly higher. A goal of the Indiana Diabetes Research Center is to leverage resources, a highly talented pool of basic and translational researchers, and a rich environment of learning and collaboration to tackle the causes, diagnoses, and treatment of diabetes and related metabolic disorders and their complications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Center Core Grants (P30)
Project #
2P30DK097512-06
Application #
9961761
Study Section
Special Emphasis Panel (ZDK1)
Program Officer
Hyde, James F
Project Start
2015-07-06
Project End
2025-05-31
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Lakshmikanthan, Sribalaji; Sobczak, Magdalena; Li Calzi, Sergio et al. (2018) Rap1B promotes VEGF-induced endothelial permeability and is required for dynamic regulation of the endothelial barrier. J Cell Sci 131:
Simons, Zachary B; Morgan, Rachel C; Rose, Laurel et al. (2018) Hypoglycemia in a Patient With a Polyhormonal Pancreatic Neuroendocrine Tumor With Evidence of Endocrine Progenitors. J Endocr Soc 2:172-177
Badin, Jill K; Kole, Ayeeshik; Stivers, Benjamin et al. (2018) Alloxan-induced diabetes exacerbates coronary atherosclerosis and calcification in Ossabaw miniature swine with metabolic syndrome. J Transl Med 16:58
Tersey, Sarah A; Levasseur, Esther M; Syed, Farooq et al. (2018) Episodic ?-cell death and dedifferentiation during diet-induced obesity and dysglycemia in male mice. FASEB J :fj201800150RR
RISE Consortium (2018) Metabolic Contrasts Between Youth and Adults With Impaired Glucose Tolerance or Recently Diagnosed Type 2 Diabetes: II. Observations Using the Oral Glucose Tolerance Test. Diabetes Care 41:1707-1716
Badin, Jill K; Bruning, Rebecca S; Sturek, Michael (2018) Effect of metabolic syndrome and aging on Ca2+ dysfunction in coronary smooth muscle and coronary artery disease severity in Ossabaw miniature swine. Exp Gerontol 108:247-255
Thompson, Kayla; Chen, Jonathan; Luo, Qianyi et al. (2018) Advanced glycation end (AGE) product modification of laminin downregulates Kir4.1 in retinal Müller cells. PLoS One 13:e0193280
Lakhter, Alexander J; Pratt, Rachel E; Moore, Rachel E et al. (2018) Beta cell extracellular vesicle miR-21-5p cargo is increased in response to inflammatory cytokines and serves as a biomarker of type 1 diabetes. Diabetologia 61:1124-1134
Li, Wei; Risacher, Shannon L; Gao, Sujuan et al. (2018) Type 2 diabetes mellitus and cerebrospinal fluid Alzheimer's disease biomarker amyloid ?1-42 in Alzheimer's Disease Neuroimaging Initiative participants. Alzheimers Dement (Amst) 10:94-98
Kono, Tatsuyoshi; Tong, Xin; Taleb, Solaema et al. (2018) Impaired Store-Operated Calcium Entry and STIM1 Loss Lead to Reduced Insulin Secretion and Increased Endoplasmic Reticulum Stress in the Diabetic ?-Cell. Diabetes 67:2293-2304

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