This is a competing A1 renewal application to the NIEHS for years 48-52 of the P30 Environmental Health Sciences Center grant. The NYU Center fosters outstanding basic environmental science research, and the investigators'vision, with the active participation of the Integrative Health Sciences Facility Core (IHSFC), is to translate their basic research results into human health studies. Since its inception just three years ago, the IHSFC has been very active in implementing this vision, expanding on the knowledge gained from prior research using cell culture or animal models. The theme of the NIEHS Center is to understand the environmental causes of disease by investigating which pollutants, genes, epigenetic programs, and cell signaling pathways influence the development of disease. The broad goals of the Center are the identification, evaluation, prevention, and control of the adverse impacts of environmental factors on human health, with strong focuses in ambient air pollution effects, environmental and occupational exposures to heavy metals, and the roles of dietary factors in the causation and prevention of human cancer and disease. Further, the Center reaches out to the community providing assistance, information, and education on environmental issues. The Center also guides its members into new research areas of interest to the NIEHS involving modern technology or research areas that are timely and may have significant environmental impact. The Center supports investigator-initiated pilot projects, as well as encourages initiatives via RFPs in new areas. The Center also supports state-of-the-art Facility Cores that are used by its members to enhance their research funded by grants from the NIEHS and other agencies. With the recent advice of their External Advisory Committee, the Center has created Focus Groups instead of research programs to promote collaboration and interactions. The Center has strengths in Early Detection and Prevention, Heavy Metal Toxicology and Carcinogenesis, Particulate Matter, and Susceptibility to Environmental Disease and has formed Focus Groups in each of these areas. Ongoing research encompassing Experimental Studies, Biomarker Development as well as Epidemiological Studies is evident across each of these Focus Groups. Thus, two leaders have been chosen for each Focus Group. One leader conducts primarily human studies (either Epidemiology or Biomarker Development), while the other leader has expertise in experimental studies or bench research. In addition, the Center formulates new plans for career development of junior faculty and for established faculty as well as evaluates the need for new technology to be provided to the members by the Facility Cores and whether new Focus Groups should be formed.

Public Health Relevance

The NYU National Institute of Environmental Health Sciences Center Grant organizes NIH-funded research into four main groups that meet to foster interaction and collaboration. The Center also supports state-of-the-art equipment and expertise that helps members of the Center carry out their research. The Center also awards small pilot projects to help investigators obtain grants and it reaches out to the community.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
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Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
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New York University
Public Health & Prev Medicine
Schools of Medicine
New York
United States
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Chen, Danqi; Fang, Lei; Li, Hongjie et al. (2018) The effects of acetaldehyde exposure on histone modifications and chromatin structure in human lung bronchial epithelial cells. Environ Mol Mutagen 59:375-385
Hua, Xiaohui; Xu, Jiheng; Deng, Xu et al. (2018) New compound ChlA-F induces autophagy-dependent anti-cancer effect via upregulating Sestrin-2 in human bladder cancer. Cancer Lett 436:38-51
Choi, Byeong Hyeok; Philips, Mark R; Chen, Yuan et al. (2018) K-Ras Lys-42 is crucial for its signaling, cell migration, and invasion. J Biol Chem 293:17574-17581
Peng, Minggang; Wang, Jingjing; Zhang, Dongyun et al. (2018) PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein. Oncogene :
Jose, Cynthia C; Jagannathan, Lakshmanan; Tanwar, Vinay S et al. (2018) Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1. Mol Carcinog 57:794-806
Choi, Byeong Hyeok; Chen, Changyan; Philips, Mark et al. (2018) RAS GTPases are modified by SUMOylation. Oncotarget 9:4440-4450
Li, Xin; Tian, Zhongxian; Jin, Honglei et al. (2018) Decreased c-Myc mRNA Stability via the MicroRNA 141-3p/AUF1 Axis Is Crucial for p63? Inhibition of Cyclin D1 Gene Transcription and Bladder Cancer Cell Tumorigenicity. Mol Cell Biol 38:
Jung, Seungyoun; Allen, Naomi; Arslan, Alan A et al. (2018) Anti-Müllerian hormone and risk of ovarian cancer in nine cohorts. Int J Cancer 142:262-270
Guo, Xirui; Huang, Haishan; Jin, Honglei et al. (2018) ISO, via Upregulating MiR-137 Transcription, Inhibits GSK3?-HSP70-MMP-2 Axis, Resulting in Attenuating Urothelial Cancer Invasion. Mol Ther Nucleic Acids 12:337-349
Weng, Mao-Wen; Lee, Hyun-Wook; Park, Sung-Hyun et al. (2018) Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis. Proc Natl Acad Sci U S A 115:E6152-E6161

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