Abstract

B. ENVIRONMENTAL HEALTH IDENTITY AND IMPACT OF RESEARCH BASE B.I. HISTORY OF ENVIRONMENTAL HEALTH SCIENCES AT THE UNIVERSITY OF ROCHESTER Research supported by the Manhattan Project in the 1940s initiated toxicology programs at the University of Rochester. Teams of scientists from different disciplines were assembled in Rochester to determine health effects of uranium, fluorides, mercury and other agents used in the process of nuclear weapons production. These endeavors focused on identifying routes of human exposure, defining mechanisms by which these elements would impair function, assessing vulnerability at different life stages, and developing approaches that could ameliorate toxicant burdens in target tissues. What emerged was an international resource in the toxicology of metals and inorganic elements that remains one of the strengths of the EHSC today.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001247-38
Application #
8378844
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
38
Fiscal Year
2012
Total Cost
$338,185
Indirect Cost
$136,001

  Institution

Name
University of Rochester
Department
Type
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Sobolewski, Marissa; Conrad, Katherine; Marvin, Elena et al. (2018) Endocrine active metals, prenatal stress and enhanced neurobehavioral disruption. Horm Behav 101:36-49
Klocke, Carolyn; Allen, Joshua L; Sobolewski, Marissa et al. (2018) Exposure to fine and ultrafine particulate matter during gestation alters postnatal oligodendrocyte maturation, proliferation capacity, and myelination. Neurotoxicology 65:196-206
McSorley, Emeir M; Yeates, Alison J; Mulhern, Maria S et al. (2018) Associations of maternal immune response with MeHg exposure at 28 weeks' gestation in the Seychelles Child Development Study. Am J Reprod Immunol 80:e13046
Duffney, Parker F; Falsetta, Megan L; Rackow, Ashley R et al. (2018) Key roles for lipid mediators in the adaptive immune response. J Clin Invest 128:2724-2731
Morris-Schaffer, Keith; Sobolewski, Marissa; Allen, Joshua L et al. (2018) Effect of neonatal hyperoxia followed by concentrated ambient ultrafine particle exposure on cumulative learning in C57Bl/6J mice. Neurotoxicology 67:234-244
Willis, Mary D; Jusko, Todd A; Halterman, Jill S et al. (2018) Unconventional natural gas development and pediatric asthma hospitalizations in Pennsylvania. Environ Res 166:402-408
Wahlberg, Karin; Love, Tanzy M; Pineda, Daniela et al. (2018) Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet. Environ Int 115:142-149
Cholette, Jill M; Pietropaoli, Anthony P; Henrichs, Kelly F et al. (2018) Elevated free hemoglobin and decreased haptoglobin levels are associated with adverse clinical outcomes, unfavorable physiologic measures, and altered inflammatory markers in pediatric cardiac surgery patients. Transfusion 58:1631-1639
Boule, Lisbeth A; Burke, Catherine G; Jin, Guang-Bi et al. (2018) Aryl hydrocarbon receptor signaling modulates antiviral immune responses: ligand metabolism rather than chemical source is the stronger predictor of outcome. Sci Rep 8:1826
Lacy, Shannon H; Woeller, Collynn F; Thatcher, Thomas H et al. (2018) Activated Human Lung Fibroblasts Produce Extracellular Vesicles with Anti-Fibrotic Prostaglandins. Am J Respir Cell Mol Biol :

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