Abstract

The Departments of Biochemistry-Molecular Biology of the University of California, Berkeley, has established a Mutagenesis Center under sponsorship of the National Institute of Environmental Health Sciences. This center unifies the efforts of a number of research groups in the Department working on various aspects of mutagenesis. A growing awareness that damage to the integrity of nucleic acids by environmental mutagens is a major problem in public health has directed many members of the Department towards more practical applications of their basic research. Eleven faculty members participate in the Center. The Mutagenesis Center's main focus in on the following research areas: 1. The detection and characterization of environmental mutagens and carcinogenes. 2. The study of mechanisms of mutagenesis and relation to carcinogenesis. 3. The study of the role of DNA damage in human disease, aging and evolution. 4. The study of DNA repair and other enzymic defenses against DNA damage and mutagenesis. 5. The study of basic mechanisms and dynamics of the genetic apparatus and chromosomes in higher organisms as related to genetic stability and toxic agent action.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES001896-24
Application #
6518022
Study Section
Special Emphasis Panel (ZES1-EBJ-C (03))
Program Officer
Dearry, Allen
Project Start
1979-02-08
Project End
2004-03-31
Budget Start
2002-04-01
Budget End
2003-03-31
Support Year
24
Fiscal Year
2002
Total Cost
$1,019,913
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
094878337
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Ye, Morgan; Warner, Marcella; Mocarelli, Paolo et al. (2018) Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study. Environ Health 17:22
Engel, Stephanie M; Bradman, Asa; Wolff, Mary S et al. (2016) Prenatal Organophosphorus Pesticide Exposure and Child Neurodevelopment at 24 Months: An Analysis of Four Birth Cohorts. Environ Health Perspect 124:822-30
Harley, Kim G; Engel, Stephanie M; Vedar, Michelle G et al. (2016) Prenatal Exposure to Organophosphorous Pesticides and Fetal Growth: Pooled Results from Four Longitudinal Birth Cohort Studies. Environ Health Perspect 124:1084-92
McHale, Cliona M; Smith, Martyn T; Zhang, Luoping (2014) Application of toxicogenomic profiling to evaluate effects of benzene and formaldehyde: from yeast to human. Ann N Y Acad Sci 1310:74-83
Chevrier, Jonathan; Warner, Marcella; Gunier, Robert B et al. (2014) Serum dioxin concentrations and thyroid hormone levels in the Seveso Women's Health Study. Am J Epidemiol 180:490-8
Wesselink, Amelia; Warner, Marcella; Samuels, Steven et al. (2014) Maternal dioxin exposure and pregnancy outcomes over 30 years of follow-up in Seveso. Environ Int 63:143-8
Vermeulen, Roel; Zhang, Luoping; Spierenburg, Annejet et al. (2012) Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene. Carcinogenesis 33:1538-41
Zhang, L; Lan, Q; Ji, Z et al. (2012) Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. Leukemia 26:2494-8
Block, Gladys; Shaikh, Nishat; Jensen, Christopher D et al. (2011) Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1. Am J Clin Nutr 94:929-37
Ren, Xuefeng; Lim, Sophia; Ji, Zhiying et al. (2011) Comparison of proliferation and genomic instability responses to WRN silencing in hematopoietic HL60 and TK6 cells. PLoS One 6:e14546

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