The fetal, neonatal, and infant developmental periods represent times in which a daunting array of environmental challenges may compromise present and long-term health. The Children's Environmental Health Sciences Core Center addresses adverse health determinants in these early stages of life. The Center proposal is founded on the partnership between investigators formerly in the Marine and Freshwater Biomedical Sciences (MFBS) Center at the University of Wisconsin-Milwaukee and the Children's Research Institute (CRI) of Children's Hospital of Wisconsin. Former MFBS Center scientists focus on environmental determinants of reproductive and developmental diseases and disorders in aquatic models, principally the zebrafish, as well as mammalian systems. The CRI contributes clinical, translational and community health investigators who are highly knowledgeable about childhood diseases and focus on this patient population in both their research and practice. The primary objective or this proposal will be to attract and strongly support numerous teams of scientists positioned along the basic, translational, and clinical/public heath sciences continuum. Their work will move the Center to national prominence in research on childhood disease and its environmental contributors. The complementary objective will be to achieve leadership in the conversion of scientific understanding into effective community education aimed at preventing environmentally influenced childhood disease. The Center will support research on the environmental roots of neurobehavioral diseases, cardiovascular birth defects and reproductive dysfunctions in relation to signal transduction/endocrine disruption, oxidative stress, and genomic variability. Research and outreach linked to the National Children's Study Vanguard Program in Waukesha, WI and freshwater/Great Lakes and children's health serve as additional integrative foci for Center activities. Center resources for clinical and community research are gathered in the Integrative Health Sciences Facility Core with its concentrated assets for patient-based studies, deep support for community studies with critical links to the Community Outreach and Educational Core (COEC), and a wealth of biostatistics infrastructure support. A companion initiative in physician-scientist career development concentrates on a research-intensive pediatric environmental health fellowship program. The Aquatic Animal Models Facility Core supports a comprehensive zebrafish husbandry and experimentation facility, a unique neurobehavioral laboratory, and specialized molecular biology and genomics infrastructure. The Imaging and Histology Facility Core affords researchers using zebrafish and mammalian models, as well as clinical researchers, state-of-the art support for microscopic analysis, histological services, and storage of biological samples. The COEC will provide national leadership in rigorous outreach and education to teachers, nurses, and socioeconomically disadvantages communities. BACKGROUND The proposed Center would be formed by strengthening the existing partnership between the well-established Marine and Freshwater Biomedical Sciences Center at the University of Wisconsin-Milwaukee with the Pediatrics Department at the Medical College of Wisconsin. The partnership currently exists as the Children's Environmental Health Institute, which has been in place since 2006. This Institute has already attracted a number of basic scientists and clinician scientists through a shared interest in environmental health and the opportunity to conduct pilot projects. Based on the application, the University also has a newly formed College of Public Health. It is possible that resources offered to this College will indirectly strengthen the proposed Center. ESSENTIAL CHARACTERISTICS Strategic Vision and Impact on Environmental Health

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Center Core Grants (P30)
Project #
Application #
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Reinlib, Leslie J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Milwaukee
Schools of Arts and Sciences
United States
Zip Code
Xu, Xiaojuan; Weber, Daniel; Martin, Amanda et al. (2016) Trans-generational transmission of neurobehavioral impairments produced by developmental methylmercury exposure in zebrafish (Danio rerio). Neurotoxicol Teratol 53:19-23
Dailey, Frank E; McGraw, Joseph E; Jensen, Brittany J et al. (2016) The Microbiota of Freshwater Fish and Freshwater Niches Contain Omega-3 Fatty Acid-Producing Shewanella Species. Appl Environ Microbiol 82:218-31
Weber, Daniel N; Hesselbach, Renee A; Petering, David H et al. (2016) Lights, Chemicals, Action: Studying Red Worms' Responses to Environmental Contaminants. Am Biol Teach 78:591-598
Laiosa, Michael D; Tate, Everett R; Ahrenhoerster, Lori S et al. (2016) Effects of Developmental Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Long-term Self-renewal of Murine Hematopoietic Stem Cells. Environ Health Perspect 124:957-65
Mora-Zamorano, Francisco X; Klingler, Rebekah; Murphy, Cheryl A et al. (2016) Parental Whole Life Cycle Exposure to Dietary Methylmercury in Zebrafish (Danio rerio) Affects the Behavior of Offspring. Environ Sci Technol 50:4808-16
Liu, Qing; Klingler, Rebekah H; Wimpee, Barbara et al. (2016) Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Reprod Toxicol 65:272-282
Mashock, Michael J; Kappell, Anthony D; Hallaj, Nadia et al. (2016) Copper oxide nanoparticles inhibit the metabolic activity of Saccharomyces cerevisiae. Environ Toxicol Chem 35:134-43
Arini, Adeline; Head, Jessica A; Murphy, Cheryl A et al. (2016) Neuroendocrine biochemical effects in methylmercury-exposed yellow perch. Comp Biochem Physiol C Toxicol Pharmacol 187:10-8
Nowakowski, Andrew B; Meeusen, Jeffrey W; Menden, Heather et al. (2015) Chemical-Biological Properties of Zinc Sensors TSQ and Zinquin: Formation of Sensor-Zn-Protein Adducts versus Zn(Sensor)2 Complexes. Inorg Chem 54:11637-47
Weber, Daniel N; Hoffmann, Raymond G; Hoke, Elizabeth S et al. (2015) Bisphenol A exposure during early development induces sex-specific changes in adult zebrafish social interactions. J Toxicol Environ Health A 78:50-66

Showing the most recent 10 out of 129 publications