The mission of the Southern California Environmental Health Sciences Center is to help reduce the burden of environmentally related diseases by providing the scientific basis for interventions to protect and enhance health, and by translating scientific findings through outreach and community engagement. The Center focuses on exploring the effects of environmental exposures across the lifecourse with an emphasis on susceptible populations, critical developmental periods, and major diseases which are mediated through shared molecular and toxicologic processes. The Center's theme is Environmental Exposures, Host Factors and Human Disease across the Lifecourse. Scientifically, the Center is organized around six Environmental Health Research Programs (Cardiorespiratory Effects, Cancer, Obesity/Metabolic Effects, Neurological Effects, Study Design and Statistical Methods, and Exposure Sciences) that are integrated by five Cross-Cutting Research Focus Areas. These programs are led by collaborative multidisciplinary teams and supported by the Center's Administrative and three Facility Cores, while findings are translated and communicated to the public through the Community Outreach and Engagement Core. The Center fosters innovative research in environmental health sciences (EHS) using the Pilot Projects Program, state-of-the-art facilities and collaborative mechanisms including the seminar series, workshops, retreats, and career development activities. Over the past 19 years, the Center has functioned as an integrated program of research excellence. The investigators have a strong research base in EHS as evidenced by our ongoing peer-reviewed research projects. The EHS identity has been further distinguished by our success in bringing together multidisciplinary research teams tackling compelling issues in EHS, attracting new and accomplished investigators to EHS, and fostering new lines of research. The Center is a national leader in community outreach and engagement, improving environmental health literacy and employing innovative approaches for community involvement and multi- directionally communicating EHS research results to community organizations, policy makers, the public health community, the news media, and the public. In the renewal period, the investigators propose to build on these approaches to promote cutting-edge science, translational research, and outreach efforts. The Center's mission, theme, structure, goals, strategic approaches, and future directions will contribute to advancing many elements of the NIEHS Strategic Plan. The broad spectrum of disciplines and expertise among their diverse Center membership's strong track record in collaborative multidisciplinary research, career development, and community engagement, positions the Center to effectively address today's critical problems and tomorrow's emerging EHS issues.

Public Health Relevance

The mission of the Southern California Environmental Health Sciences Center is to reduce the burden of environmentally related diseases through better characterization of environmental threats to public health, increased understanding of the basis for personal vulnerability, community engagement and translation of research to support prevention efforts now and into the future.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007048-24
Application #
9672308
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Thompson, Claudia L
Project Start
1997-04-01
Project End
2021-03-31
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
24
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Southern California
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Liu, Gang; Mukherjee, Bhramar; Lee, Seunggeun et al. (2018) Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence. Am J Epidemiol 187:366-377
Wheelock, Kylie; Zhang, Junfeng Jim; McConnell, Rob et al. (2018) A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons. Environ Sci Process Impacts :
Younan, Diana; Tuvblad, Catherine; Franklin, Meredith et al. (2018) Longitudinal Analysis of Particulate Air Pollutants and Adolescent Delinquent Behavior in Southern California. J Abnorm Child Psychol 46:1283-1293
Barrington-Trimis, Jessica L; Leventhal, Adam M; Alonzo, Todd A et al. (2018) Performance of cigarette susceptibility index among e-cigarette and hookah users. Drug Alcohol Depend 183:43-50
Ogasawara, Noriko; Poposki, Julie A; Klingler, Aiko I et al. (2018) IL-10, TGF-?, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol 141:1147-1151.e8
Urman, Robert; McConnell, Rob; Unger, Jennifer B et al. (2018) Electronic Cigarette and Cigarette Social Environments and Ever Use of Each Product: A Prospective Study of Young Adults in Southern California. Nicotine Tob Res :
Farzan, Shohreh F; Howe, Caitlin G; Chen, Yu et al. (2018) Prenatal lead exposure and elevated blood pressure in children. Environ Int 121:1289-1296
Cho, Junhan; Goldenson, Nicholas I; Stone, Matthew D et al. (2018) Characterizing Polytobacco Use Trajectories and Their Associations With Substance Use and Mental Health Across Mid-Adolescence. Nicotine Tob Res 20:S31-S38
Moss, Lilit C; Gauderman, William J; Lewinger, Juan Pablo et al. (2018) Using Bayes model averaging to leverage both gene main effects and G?×? E interactions to identify genomic regions in genome-wide association studies. Genet Epidemiol :
Chen, Wansu; Qian, Lei; Shi, Jiaxiao et al. (2018) Comparing performance between log-binomial and robust Poisson regression models for estimating risk ratios under model misspecification. BMC Med Res Methodol 18:63

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