Abstract

Overall Objectives and Specific Aims The overall objective of this Facility Core is to provide both routine histology processing, as well as more specialized histochemical and immunohistochemical techniques to Center investigators. This Core also provides technical assistance, training, and consultations in histological techniques, necropsies and histopathological interpretation for Center investigators.
The Specific Aims of Facility Core 3 are: 1. To provide histology processing, including paraffin embedding, staining, frozen sections, and other conventional histology techniques required by Center Members; 2. To continue developing novel necropsy, morphometry (sample collection, orientation and processing) and immunohistochemical approaches precisely adapted to the needs of Center Members; 3. To provide training, advice and consultation for morphology techniques and for the histo- and immunopathologic diagnosis of experimental lesions to Center Members; 4. To provide more formalized instruction in histopathology in the context of new initiatives of the Career Development Core; 5. To identify, develop and implement new techniques as needed to support the initiatives developed by the Integrated Health Science Facility Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES007784-13
Application #
7799105
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2009-04-01
Budget End
2010-03-31
Support Year
13
Fiscal Year
2009
Total Cost
$158,521
Indirect Cost

  Institution

Name
University of Texas MD Anderson Cancer Center
Department
Type
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Han, Ying; Rand, Kristin A; Hazelett, Dennis J et al. (2016) Prostate Cancer Susceptibility in Men of African Ancestry at 8q24. J Natl Cancer Inst 108:
Rand, Kristin A; Rohland, Nadin; Tandon, Arti et al. (2016) Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk. Hum Mol Genet 25:371-81
Rand, Kristin A; Song, Chi; Dean, Eric et al. (2016) A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci. Cancer Epidemiol Biomarkers Prev 25:1609-1618
Cifarelli, V; Hursting, S D (2015) Obesity, Diabetes and Cancer: A Mechanistic Perspective. Int J Diabetol Vasc Dis Res 2015:
Rao, Dharanija; Macias, Everardo; Carbajal, Steve et al. (2015) Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. Mol Carcinog 54:121-33
Han, Ying; Signorello, Lisa B; Strom, Sara S et al. (2015) Generalizability of established prostate cancer risk variants in men of African ancestry. Int J Cancer 136:1210-7
Takata, Kei-Ichi; Tomida, Junya; Reh, Shelley et al. (2015) Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ? (POLN). J Biol Chem 290:24278-93
Han, Ying; Hazelett, Dennis J; Wiklund, Fredrik et al. (2015) Integration of multiethnic fine-mapping and genomic annotation to prioritize candidate functional SNPs at prostate cancer susceptibility regions. Hum Mol Genet 24:5603-18
Nowinski, Sara M; Solmonson, Ashley; Rundhaug, Joyce E et al. (2015) Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nat Commun 6:8137
Sarkar, Jayanta; Dominguez, Emily; Li, Guojun et al. (2014) Modeling gene-environment interactions in oral cavity and esophageal cancers demonstrates a role for the p53 R72P polymorphism in modulating susceptibility. Mol Carcinog 53:648-58

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