of the Study Design and Data Analytics Facility Core (Data FC) In the present application, the Center for Environmental Health in Northern Manhattan (CEHNM) will support three facility cores (FCs)?the Integrative Health Sciences Facility Core (IHSFC), the Exposure Assessment FC (Exposure FC), and the new Study Design and Data Analytics Facility Core (Data FC). The FCs will facilitate different aspects of the members? basic, patient-oriented, population-based, and translational research. Under IHSFC?s central coordination, the three FCs will form a highly effective pipeline of science to support members with a wide array of study design, exposure assessment, wet-lab, and data services throughout all the stages of their investigations. To empower this structure, we propose the new Data FC, which addresses the growing need for using complex design and advanced computational methods and tools in environmental health sciences. CEHNM has a long, highly successful record of study design, data management, and biostatistical support, which are currently offered by the IHSFC. We will transfer these services in the new and augmented Data FC. The Data FC will offer unique expertise, services, and resources to assist investigators from study conception through results dissemination. The Data FC will provide intellectual and computational infrastructure to plan, conduct and analyze studies by continuing to support existing services, which have a long-standing record of success within the CEHNM, including: (i) design of observational, clinical and experimental studies; (ii) biostatistical consultations; and (iii) data management. In this Center renewal, members will find in the Data FC highly expanded capacity, including: (iv) processing and analysis of a variety of ?omics data; (v) training and guidance on handling and analyzing Geographical Information Systems (GIS) data; and (vi) identifying, accessing, and analyzing the growing number of large data repositories in the public domain. Throughout these activities, the Data FC will (vii) offer educational programs on the use of these methods, while (viii) fostering attention to the development of new methods and tools. The unique combination of new and existing services in the new Data FC will multiply opportunities and effectiveness in using the rich data that CEHNM members generate?as well as those already available in-house or in the public domain?to answer groundbreaking questions in environmental health research. We have a unique opportunity to create this Data FC, because we can build on our extremely successful record of study design and data support, currently provided by the IHSFC. Over the first 4 years of the current grant cycle (2013-2016), CEHNM provided study design, data management, and biostatistical support to 45 pilot grant submissions/projects, 50 grant submissions (12 funded), and 16 pre- and 6 post-doctoral projects. These services directly supported 118 publications.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES009089-21
Application #
9672447
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2019-04-01
Budget End
2020-03-31
Support Year
21
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Huang, Jian V; Cardenas, Andres; Colicino, Elena et al. (2018) DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence. Epigenetics :1-16
Perzanowski, Matthew S; Savary, Khalil W; Arteaga-Solis, Emilio et al. (2018) Associations between Parasympathetic Activity in the Month after Birth and Wheeze at Age 2-3 Years. Am J Respir Crit Care Med 198:532-534
Cowell, Whitney J; Sjödin, Andreas; Jones, Richard et al. (2018) Determinants of prenatal exposure to polybrominated diphenyl ethers (PBDEs) among urban, minority infants born between 1998 and 2006. Environ Pollut 233:774-781
Haque, Ezazul; Mailloux, Brian J; de Wolff, Daisy et al. (2018) Quantitative drinking water arsenic concentrations in field environments using mobile phone photometry of field kits. Sci Total Environ 618:579-585
Wu, Shaowei; Gennings, Chris; Wright, Rosalind J et al. (2018) Prenatal Stress, Methylation in Inflammation-Related Genes, and Adiposity Measures in Early Childhood: the Programming Research in Obesity, Growth Environment and Social Stress Cohort Study. Psychosom Med 80:34-41
Weinberger, Kate R; Kinney, Patrick L; Robinson, Guy S et al. (2018) Levels and determinants of tree pollen in New York City. J Expo Sci Environ Epidemiol 28:119-124
Gould, Carlos F; Chillrud, Steven N; Phillips, Douglas et al. (2018) Soot and the city: Evaluating the impacts of Clean Heat policies on indoor/outdoor air quality in New York City apartments. PLoS One 13:e0199783
Tian, Fu-Ying; Rifas-Shiman, Sheryl L; Cardenas, Andres et al. (2018) Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva. Int J Obes (Lond) :
Wasserman, Gail A; Liu, Xinhua; Parvez, Faruque et al. (2018) A cross-sectional study of water arsenic exposure and intellectual function in adolescence in Araihazar, Bangladesh. Environ Int 118:304-313
Lovinsky-Desir, Stephanie; Lawrence, Jennifer; Jung, Kyung Hwa et al. (2018) Assessment of exposure to air pollution in children: Determining whether wearing a personal monitor affects physical activity. Environ Res 166:340-343

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