The proposed Center for Environmental and Rural Health (CERH) at Texas A & M University will foster and promote basic and applied science programs which are focused on the impacts of environmental factors on human health. Particular emphasis will be placed on understanding environmental and nutritional components of human disease with specific emphasis on their effects on rural communities. Environmentally-related diseases involve exposure to chemicals or physical factors that interact with the host to disrupt cell, tissue, and ultimately organ homeostasis. Thus, effective management of environmental disorders requires a comprehensive understanding of cellular and molecular mechanisms of toxic injury. As part of the Center initiatives, research efforts will focus on the study of genetic basis of susceptibility to environmental factors taking advantage of genetic manipulation technologies. The development of measures that minimize the negative health outcomes associated with environmental exposures has often been limited by accessibility to target populations. An often under utilized strategy in the study of environmentally-related diseases has been nutritional intervention to modulate outcomes associated with exposure to environmental chemicals and related insults. Thus, Center efforts will be directed at the study of nutritional factors which influence the onset and progression of environmentally-related diseases in laboratory animals and in human populations. Finally, the development of methods for the detection, prevention, and control of environmentally-related diseases in rural communities will be accomplished by integrating the efforts of basic scientists, epidemiologists and biostatisticians. The Center will consist of 4 Research Cores (Cellular and Molecular Biology, Reproductive and Developmental Biology, Nutrition, and Biostatistics and Epidemiology) which will utilize 6 Facilities Cores (DNA Technology, Biostatistics and Computational, Field Services, Image Analysis, Transgenics, and Biological Mass Spectrometry). An Outreach Core will focus on interaction with rural communities and a Pilot Project Program will facilitate research interaction with potential new CERH members. An Administrative Core will coordinate activities of the proposed Center. Funding of the Center will synergistically enhance faculty research on important environmental health problems which impact rural populations and also provide an important linkage with the new School of Public Health being developed at Texas A & M University.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
3P30ES009106-03S1
Application #
6346493
Study Section
Special Emphasis Panel (ZES1 (P1))
Program Officer
Dearry, Allen
Project Start
1998-04-05
Project End
2002-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
3
Fiscal Year
2000
Total Cost
$90,000
Indirect Cost
Name
Texas A&M University
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047006379
City
College Station
State
TX
Country
United States
Zip Code
77845
Fan, Yang-Yi; Vaz, Frederic M; Chapkin, Robert S (2017) Dietary fat and fiber interactively modulate apoptosis and mitochondrial bioenergetic profiles in mouse colon in a site-specific manner. Eur J Cancer Prev 26:301-308
Safe, Stephen; Jin, Un-Ho; Morpurgo, Benjamin et al. (2016) Nuclear receptor 4A (NR4A) family - orphans no more. J Steroid Biochem Mol Biol 157:48-60
Davidson, Laurie A; Callaway, Evelyn S; Kim, Eunjoo et al. (2015) Targeted Deletion of p53 in Lgr5-Expressing Intestinal Stem Cells Promotes Colon Tumorigenesis in a Preclinical Model of Colitis-Associated Cancer. Cancer Res 75:5392-7
Hedrick, Erik; Crose, Lisa; Linardic, Corinne M et al. (2015) Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. Mol Cancer Ther 14:2143-53
Phillips, Tracie D; Richardson, Molly; Cheng, Yi-Shing Lisa et al. (2015) Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch Toxicol 89:967-77
Feng, Lingfang; Zhang, Yue; Jiang, Mizu et al. (2015) Up-regulation of Gadd45? after exposure to metal nanoparticles: the role of hypoxia inducible factor 1?. Environ Toxicol 30:490-9
Barhoumi, Rola; Mouneimne, Youssef; Chapkin, Robert S et al. (2014) Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells. PLoS One 9:e90908
Bellum, Sairam; Thuett, Kerry A; Bawa, Bhupinder et al. (2013) The effect of methylmercury exposure on behavior and cerebellar granule cell physiology in aged mice. J Appl Toxicol 33:959-69
Shaikh, Saame Raza; Jolly, Christopher A; Chapkin, Robert S (2012) n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization. Mol Aspects Med 33:46-54
Franco, S L M; Swenson, G J; Long, R A (2012) Year round patchiness of Vibrio vulnificus within a temperate Texas bay. J Appl Microbiol 112:593-604

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