The goal of the Molecular Analysis Facility Core (MAFC) is to support Center members, especially those in the Pilot Projects Program and the three Translational Research focus areas (Environmental Cancer, Cardiopulmonary Disease, and Developmental Disease), by ensuring access to analytical resources within the MAFC sub-core facilities (Biomarker Mass Spectrometry, DNA Damage, Genome Sciences, and Translational Pathology Laboratory). Support includes consultation and experimental design, routine sample analysis and training, development of novel analytical methods needed to advance research, and in-depth data analysis, integration, and interpretation. The MAFC will achieve this goal through the following four specific aims: 1) Ensure efficient operations in the MAFC sub-core facilities, upgrading instrumentation and services to meet analytical needs of UNC-CEHS members; 2) Foster a collaborative, learning environment in which MAFC personnel and UNC-CEHS investigators can develop new competencies and research collaborations; 3) Strengthen the partnership between the IHSFC, BBFC and MAFC to enhance the value of data generated in the MAFC and to assist investigators with data integration; and 4) Increase visibility and promote capabilities of the MAFC sub-cores to attract new researchers in environmental health sciences.
These aims will contribute to the overall mission of the UNC Center for Environmental Health and Susceptibility by providing consolidated and cost-effective analytical services and technical expertise to Center members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES010126-17
Application #
9607991
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Thompson, Claudia L
Project Start
Project End
Budget Start
2018-04-01
Budget End
2019-03-31
Support Year
17
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Barrington, William T; Wulfridge, Phillip; Wells, Ann E et al. (2018) Improving Metabolic Health Through Precision Dietetics in Mice. Genetics 208:399-417
Cui, Tianqu; Zeng, Zhexi; Dos Santos, Erickson O et al. (2018) Development of a hydrophilic interaction liquid chromatography (HILIC) method for the chemical characterization of water-soluble isoprene epoxydiol (IEPOX)-derived secondary organic aerosol. Environ Sci Process Impacts 20:1524-1536
Robbins, Zachary; Bodnar, Wanda; Zhang, Zhenfa et al. (2018) Trisaminohexyl isocyanurate, a urinary biomarker of HDI isocyanurate exposure. J Chromatogr B Analyt Technol Biomed Life Sci 1076:117-129
Pietryk, Edward W; Clement, Kiristin; Elnagheeb, Marwa et al. (2018) Intergenerational response to the endocrine disruptor vinclozolin is influenced by maternal genotype and crossing scheme. Reprod Toxicol 78:9-19
Marks, Daniel L; Blackmon, Richard L; Oldenburg, Amy L (2018) Diffusion tensor optical coherence tomography. Phys Med Biol 63:025007
Sarnowski, ChloƩ; Kavousi, Maryam; Isaacs, Steve et al. (2018) Genetic variants associated with earlier age at menopause increase the risk of cardiovascular events in women. Menopause 25:451-457
Kelley, Dannielle E; Boynton, Marcella H; Noar, Seth M et al. (2018) Effective Message Elements for Disclosures About Chemicals in Cigarette Smoke. Nicotine Tob Res 20:1047-1054
Doherty, Brett T; Hoffman, Kate; Keil, Alexander P et al. (2018) Prenatal exposure to organophosphate esters and cognitive development in young children in the Pregnancy, Infection, and Nutrition Study. Environ Res 169:33-40
Wang, Ting; Wang, Xiaofei; Zhou, Haibo et al. (2018) Auxiliary variable-enriched biomarker-stratified design. Stat Med 37:4610-4635
Isom, Daniel G; Page, Stephani C; Collins, Leonard B et al. (2018) Coordinated regulation of intracellular pH by two glucose-sensing pathways in yeast. J Biol Chem 293:2318-2329

Showing the most recent 10 out of 1900 publications