The overarching goal of the Integrated Health Sciences Facility Core (IHSFC) is to support Center members, especially those in the Pilot Projects Program and the three Translational Research focus areas (Environmental Cancer, Cardiopulmonary Disease, and Developmental Disease), by facilitating translation of fundamental research to human populations. Specifically, IHSFC addresses this goal by providing integrated consultation to investigators planning projects that include human biospecimens, ensuring access to numerous molecular epidemiological studies with data and biospecimen resources aimed at environmental research, and by ensuring access to the Biospecimen Processing sub-Core Facility (BSP). The Biospecimen Processing IHSFC sub-Core Facility (BSP), provides full service sample collection, processing, analysis and storage services. The IHSFC also interacts closely with the Biostatistics and Bioinformatics Facility Core and the Molecular Analysis Facility Core to support molecular epidemiological studies. The IHSFC will achieve its goal through the following specific aims: 1) Provide scientific consultation for and tracking of clinical and translational human subjects studies; 2) Assist with collection, processing, analysis, and storage of biospecimens; and 3) Facilitate access to collaborative human studies.
These aims will contribute to the overall mission of the UNC Center for Environmental Health and Susceptibility by providing consolidated and cost- effective collection, processing, analysis and storage services and molecular epidemiological expertise to Center members.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
5P30ES010126-19
Application #
9903309
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
19
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zheng, Xiaojing; O'Connell, Catherine M; Zhong, Wujuan et al. (2018) Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease. J Immunol 200:2941-2956
Orlow, Irene; Shi, Yang; Kanetsky, Peter A et al. (2018) The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival. Pigment Cell Melanoma Res 31:287-296
Herceg, Zdenko; Ghantous, Akram; Wild, Christopher P et al. (2018) Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer 142:874-882
Tappata, Manaswita; Eluri, Swathi; Perjar, Irina et al. (2018) Association of mast cells with clinical, endoscopic, and histologic findings in adults with eosinophilic esophagitis. Allergy 73:2088-2092
Hoffman, Kate; Stapleton, Heather M; Lorenzo, Amelia et al. (2018) Prenatal exposure to organophosphates and associations with birthweight and gestational length. Environ Int 116:248-254
Little, Michael S; Pellock, Samuel J; Walton, William G et al. (2018) Structural basis for the regulation of ?-glucuronidase expression by human gut Enterobacteriaceae. Proc Natl Acad Sci U S A 115:E152-E161
Anderson, Chelsea; Milne, Ginger L; Park, Yong-Moon Mark et al. (2018) Cardiovascular disease risk factors and oxidative stress among premenopausal women. Free Radic Biol Med 115:246-251
Bhatt, Aadra P; Gunasekara, Dulan B; Speer, Jennifer et al. (2018) Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells. ACS Infect Dis 4:46-52
Laudermilk, Lucas T; Thomas, Joseph M; Kelada, Samir N (2018) Differential Regulation of Zfp30 Expression in Murine Airway Epithelia Through Altered Binding of ZFP148 to rs51434084. G3 (Bethesda) 8:687-693
Butler, EboneƩ N; Bensen, Jeannette T; Chen, Mengjie et al. (2018) Prediagnostic Smoking Is Associated with Binary and Quantitative Measures of ER Protein and ESR1 mRNA Expression in Breast Tumors. Cancer Epidemiol Biomarkers Prev 27:67-74

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