Abstract

The Systems Biology Core, directed by Eberhard Voit, is composed of an educational component and a service component. The goal of the core is to educate HERCULES investigators on how systems biology approaches can help generate data that can be used in higher-level exposome models. The service component will provide bioinformatic, biostatistical, and systems biology support for all HERCULES investigators. The Integrated Health Sciences Facility Core, directed by Dean Jones, will provide three central functions within the Center, support of clinical research services, personalized exposure surveillance using a top-down high-resolution metabolomics method and targeted exposure analysis using mass spectrometry, immunoassay and chemical sensor methods. The core will facilitate translational and clinical studies by providing access and expertise with several well-characterized human/clinical populations. The IHSFC will act at the interface of the exposome and clinical and public health practice.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Center Core Grants (P30)
Project #
1P30ES019776-01A1
Application #
8482233
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
Project End
Budget Start
2013-05-21
Budget End
2014-03-31
Support Year
1
Fiscal Year
2013
Total Cost
$128,525
Indirect Cost
$14,000

  Institution

Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Deyssenroth, Maya A; Gennings, Chris; Liu, Shelley H et al. (2018) Intrauterine multi-metal exposure is associated with reduced fetal growth through modulation of the placental gene network. Environ Int 120:373-381
Niedzwiecki, Megan M; Samant, Pradnya; Walker, Douglas I et al. (2018) Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics. Anal Chem 90:3786-3792
Monastero, Rebecca N; Vacchi-Suzzi, Caterina; Marsit, Carmen et al. (2018) Expression of Genes Involved in Stress, Toxicity, Inflammation, and Autoimmunity in Relation to Cadmium, Mercury, and Lead in Human Blood: A Pilot Study. Toxics 6:
Balakrishnan, Poojitha; Navas-Acien, Ana; Haack, Karin et al. (2018) Arsenic-gene interactions and beta-cell function in the Strong Heart Family Study. Toxicol Appl Pharmacol 348:123-129
Everson, Todd M; Punshon, Tracy; Jackson, Brian P et al. (2018) Cadmium-Associated Differential Methylation throughout the Placental Genome: Epigenome-Wide Association Study of Two U.S. Birth Cohorts. Environ Health Perspect 126:017010
Liang, Donghai; Moutinho, Jennifer L; Golan, Rachel et al. (2018) Use of high-resolution metabolomics for the identification of metabolic signals associated with traffic-related air pollution. Environ Int 120:145-154
Huang, Yunfeng; Hui, Qin; Walker, Douglas I et al. (2018) Untargeted metabolomics reveals multiple metabolites influencing smoking-related DNA methylation. Epigenomics 10:379-393
Walker, Douglas I; Lane, Kevin J; Liu, Ken et al. (2018) Metabolomic assessment of exposure to near-highway ultrafine particles. J Expo Sci Environ Epidemiol :
Samant, Pradnya P; Prausnitz, Mark R (2018) Mechanisms of sampling interstitial fluid from skin using a microneedle patch. Proc Natl Acad Sci U S A 115:4583-4588
Niedzwiecki, Megan M; Walker, Douglas I; Vermeulen, Roel et al. (2018) The Exposome: Molecules to Populations. Annu Rev Pharmacol Toxicol :

Showing the most recent 10 out of 145 publications