In this application we request continuing support for a Center for Vision Research in the Department of Ophthalmology. The funds will provide investigators in our Center shared resources that are vital for the continuation of current research programs and efficient development of new programs. our Center is structured into 6 discrete resource/service Modules: Machine Shop; Electronics/Computers Instrumentation; Research Photography-Imaging; Tissue Culture; Shared Equipment; and Cellular Imaging. In addition to enhancing the research environment and productivity by providing common centralized services, our Center stimulates and facilitates collaborative studies and strives to attract to vision research scientists in other health-related disciplines. our group consists of 10 independent investigators who have NEI grants complemented with several associate investigators and fellows. Research is conducted in several scientific disciplines such as biochemistry, pharmacology, physiology, cell biology, and neurology. Areas of active research include glaucoma, cataracts, corneal diseases, aqueous humor dynamics, physiology of fluid and electrolyte transport in cornea, lens and ciliary epithelium, role of membrane receptors in regulation of intraocular pressure, electroretinogram and visual evoked potentials in eye diseases, visual control of the oculomotor system, and morphology and function of central optic pathways. The support of the CORE Center grant is complemented by a strong commitment of the Department and the Mount Sinai Medical Center to excellence in vision research. Our Department has completed a floor renovation which provided 5,000 sq. feet of new research space, major equipment and laboratories for 2 new independent investigators. NEI funds are requested for 4 of the 6 modules, with the 2 newest modules (Shared Equipment and Cell Imaging) supported by the Department and individual investigators.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
2P30EY001867-19
Application #
2158250
Study Section
Special Emphasis Panel (SRC (02))
Project Start
1977-02-01
Project End
2000-06-30
Budget Start
1995-07-01
Budget End
1996-06-30
Support Year
19
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029
Alvarez, Lawrence J; Zamudio, Aldo C; Candia, Oscar A (2013) Sildenafil stimulates aqueous humor turnover in rabbits. Exp Eye Res 111:67-70
Gerometta, Rosana; Kumar, Sandeep; Shah, Shaily et al. (2013) Reduction of steroid-induced intraocular pressure elevation in sheep by tissue plasminogen activator. Invest Ophthalmol Vis Sci 54:7903-9
Wang, Lingyan; Ly, Christine M; Ko, Chun-Ying et al. (2012) uPA binding to PAI-1 induces corneal myofibroblast differentiation on vitronectin. Invest Ophthalmol Vis Sci 53:4765-75
Gerometta, Rosana; Alvarez, Lawrence J; Candia, Oscar A (2012) Sildenafil accelerates anterior chamber refilling after paracentesis in sheep and rabbits. Invest Ophthalmol Vis Sci 53:565-73
Candia, Oscar A; Mathias, Richard; Gerometta, Rosana (2012) Fluid circulation determined in the isolated bovine lens. Invest Ophthalmol Vis Sci 53:7087-96
Wang, Lingyan; Pedroja, Benjamin S; Meyers, Erin E et al. (2012) Degradation of internalized ?v?5 integrin is controlled by uPAR bound uPA: effect on ?1 integrin activity and ?-SMA stress fiber assembly. PLoS One 7:e33915
Zamudio, Aldo C; Candia, Oscar A (2011) Interaction between mechanical and osmotic forces in the isolated rabbit lens. Exp Eye Res 93:798-803
Gerometta, Rosana; Escobar, D; Candia, Oscar A (2011) An hypothesis on pressure transmission from anterior chamber to optic nerve. Med Hypotheses 77:827-31
Yakushin, Sergei B; Dai, Mingjia; Raphan, Theodore et al. (2011) Spatial orientation of the angular vestibulo-ocular reflex (aVOR) after semicircular canal plugging and canal nerve section. Exp Brain Res 210:583-94
Trexler, E Brady; Casti, Alexander R R; Zhang, Yu (2011) Nonlinearity and noise at the rod-rod bipolar cell synapse. Vis Neurosci 28:61-8

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