Abstract

Funds are requested to renew core support for 4 core modules. I. Tissue Culture. This laboratory provides modern facilities for the culture of a variety of ocular cells used in different research projects. Five primary and 11 secondary users base important aspects of their research on this laboratory. Core support is requested for a supervisor and basic supplies. II. Histopathology. This important laboratory provides all facilities for tissue processing for light microscopy. It is heavily utilized with 10 primary and 11 secondary users. Core support is requested for a supervisor and basic supplies. III. Ultrastructure (EM). This laboratory provides all equipment and support for scanning and transmission electron microscopy. It is used to full capacity by 5 primary and 17 secondary users. Core support is requested for a supervisor and basic supplies. IV. Vivarium. This modern facility accommodates primates, rodents, rabbits and cats and provides for sterile surgery and special procedures such as necropsy, electroretinography, echography and fundus photography. The vivarium is essential to our entire basic science research effort with 11 primary and 4 secondary users. Core support is requested for a supervisor, a senior vivarium technician and basic supplies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
3P30EY003040-10S1
Application #
3102568
Study Section
Vision Research and Training Committee (VSN)
Project Start
1979-09-30
Project End
1990-02-28
Budget Start
1988-09-30
Budget End
1990-02-28
Support Year
10
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Doheny Eye Institute
Department
Type
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90033

  Publications

Kim, Hwa Sun; Huang, Shun-Ping; Lee, Eun-Jin et al. (2018) Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. Adv Exp Med Biol 1074:281-287
Gonzalez Jr, Jose M; Ko, Minhee K; Masedunskas, Andrius et al. (2017) Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res 158:161-170
Carelli, Valerio; La Morgia, Chiara; Ross-Cisneros, Fred N et al. (2017) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26:R139-R150
Kim, Esther Lee; Tran, Jeffrey; Töteberg-Harms, Marc et al. (2017) Vision Loss and Recovery after Baerveldt Aqueous Tube Shunt Implantation. J Ophthalmol 2017:4140305
Ishikawa, Keijiro; Sreekumar, Parameswaran G; Spee, Christine et al. (2016) ?B-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. Am J Pathol 186:859-73
Ko, MinHee K; Kim, Eun Kyoung; Gonzalez Jr, Jose M et al. (2016) Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues. Sci Rep 6:21492
Francis, Brian A; Loewen, Nils; Hong, Bryan et al. (2016) Repeatability of selective laser trabeculoplasty for open-angle glaucoma. BMC Ophthalmol 16:128
Lima, Luiz H; Morales, Yael; Cabral, Thiago (2016) Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM). J Ophthalmol 2016:5356371
Eandi, Chiara M; Charles Messance, Hugo; Augustin, Sébastien et al. (2016) Subretinal mononuclear phagocytes induce cone segment loss via IL-1?. Elife 5:
Boado, Ruben J; Lu, Jeff Zhiqiang; Hui, Eric Ka-Wai et al. (2016) Insulin Receptor Antibody-?-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts. Mol Pharm 13:1385-92

Showing the most recent 10 out of 968 publications