Funds are requested to renew core support for 4 core modules. I. Tissue Culture. This laboratory provides modern facilities for the culture of a variety of ocular cells used in different research projects. Five primary and 11 secondary users base important aspects of their research on this laboratory. Core support is requested for a supervisor and basic supplies. II. Histopathology. This important laboratory provides all facilities for tissue processing for light microscopy. It is heavily utilized with 10 primary and 11 secondary users. Core support is requested for a supervisor and basic supplies. III. Ultrastructure (EM). This laboratory provides all equipment and support for scanning and transmission electron microscopy. It is used to full capacity by 5 primary and 17 secondary users. Core support is requested for a supervisor and basic supplies. IV. Vivarium. This modern facility accommodates primates, rodents, rabbits and cats and provides for sterile surgery and special procedures such as necropsy, electroretinography, echography and fundus photography. The vivarium is essential to our entire basic science research effort with 11 primary and 4 secondary users. Core support is requested for a supervisor, a senior vivarium technician and basic supplies.

National Institute of Health (NIH)
National Eye Institute (NEI)
Center Core Grants (P30)
Project #
Application #
Study Section
Vision Research and Training Committee (VSN)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Doheny Eye Institute
Los Angeles
United States
Zip Code
Kim, Hwa Sun; Huang, Shun-Ping; Lee, Eun-Jin et al. (2018) Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice. Adv Exp Med Biol 1074:281-287
Gonzalez Jr, Jose M; Ko, Minhee K; Masedunskas, Andrius et al. (2017) Toward in vivo two-photon analysis of mouse aqueous outflow structure and function. Exp Eye Res 158:161-170
Carelli, Valerio; La Morgia, Chiara; Ross-Cisneros, Fred N et al. (2017) Optic neuropathies: the tip of the neurodegeneration iceberg. Hum Mol Genet 26:R139-R150
Kim, Esther Lee; Tran, Jeffrey; Töteberg-Harms, Marc et al. (2017) Vision Loss and Recovery after Baerveldt Aqueous Tube Shunt Implantation. J Ophthalmol 2017:4140305
Lima, Luiz H; Morales, Yael; Cabral, Thiago (2016) Ocular Biocompatibility of Poly-N-Isopropylacrylamide (pNIPAM). J Ophthalmol 2016:5356371
Eandi, Chiara M; Charles Messance, Hugo; Augustin, Sébastien et al. (2016) Subretinal mononuclear phagocytes induce cone segment loss via IL-1?. Elife 5:
Boado, Ruben J; Lu, Jeff Zhiqiang; Hui, Eric Ka-Wai et al. (2016) Insulin Receptor Antibody-?-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts. Mol Pharm 13:1385-92
Kochounian, Harold; Zhang, Zhaoxia; Spee, Christine et al. (2016) Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Mol Vis 22:213-23
Deming, Janise D; Van Craenenbroeck, Kathleen; Eom, Yun Sung et al. (2016) Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4. Adv Exp Med Biol 854:663-70
Choudhury, Farzana; Varma, Rohit; Klein, Ronald et al. (2016) Age-Related Macular Degeneration and Quality of Life in Latinos: The Los Angeles Latino Eye Study. JAMA Ophthalmol 134:683-90

Showing the most recent 10 out of 968 publications