Abstract

The objective of this proposal is to promote cooperative vision research at Wayne State University through the establishment of a Core Vision Research Group supported by a Core Vision Research Grant. The Core Vision Research Grant will establish the following centralized facilities for eye research. An electron Microscopy-Freeze Etch module; a Biochemistry module; and Electronics and Computer Engineering module, a Cell and Tissue culture module, and an Administration module. The Core Vision Research Group will enhance eye research primarily within the University and other nearbvy institutions. It will encompass studies on the cornea, lens, retina and visual connections. These studies will utilize ultrastructural, biochemical, physiological and biophysical research strategies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY004068-05
Application #
3102601
Study Section
Vision Research and Training Committee (VSN)
Project Start
1982-04-01
Project End
1987-03-31
Budget Start
1986-04-01
Budget End
1987-03-31
Support Year
5
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Wayne State University
Department
Type
Schools of Medicine
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202

  Publications

Curtiss, Elizabeth; Jiang, Youde; Liu, Li et al. (2018) Epac1 Restores Normal Insulin Signaling through a Reduction in Inflammatory Cytokines. Mediators Inflamm 2018:3809092
Singh, Pawan Kumar; Khatri, Indu; Jha, Alokkumar et al. (2018) Determination of system level alterations in host transcriptome due to Zika virus (ZIKV) Infection in retinal pigment epithelium. Sci Rep 8:11209
Han, Jing; Li, Yue; Liu, Xiuli et al. (2018) Metformin suppresses retinal angiogenesis and inflammation in vitro and in vivo. PLoS One 13:e0193031
Berkowitz, Bruce A; Podolsky, Robert H; Berri, Ali M et al. (2018) Dark Rearing Does Not Prevent Rod Oxidative Stress In Vivo in Pde6brd10 Mice. Invest Ophthalmol Vis Sci 59:1659-1665
Jiang, Youde; Liu, Li; Steinle, Jena J (2018) miRNA15a regulates insulin signal transduction in the retinal vasculature. Cell Signal 44:28-32
Liu, Li; Patel, Paragi; Steinle, Jena J (2018) PKA regulates HMGB1 through activation of IGFBP-3 and SIRT1 in human retinal endothelial cells cultured in high glucose. Inflamm Res 67:1013-1019
Carion, Thomas W; Greenwood, Matthew; Ebrahim, Abdul Shukkur et al. (2018) Immunoregulatory role of 15-lipoxygenase in the pathogenesis of bacterial keratitis. FASEB J 32:5026-5038
Shi, Haoshen; Berger, Elizabeth A (2018) Characterization of Site-Specific Phosphorylation of NF-?B p65 in Retinal Cells in Response to High Glucose and Cytokine Polarization. Mediators Inflamm 2018:3020675
Guest, John M; Singh, Pawan Kumar; Revankar, Sanjay G et al. (2018) Isavuconazole for Treatment of Experimental Fungal Endophthalmitis Caused by Aspergillus fumigatus. Antimicrob Agents Chemother 62:
Berkowitz, Bruce A; Podolsky, Robert H; Qian, Haohua et al. (2018) Mitochondrial Respiration in Outer Retina Contributes to Light-Evoked Increase in Hydration In Vivo. Invest Ophthalmol Vis Sci 59:5957-5964

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