Mass Spectrometry and Molecular Biology Module Abstract The objective of the Mass Spectrometry and Molecular Biology Module is to enhance the capabilities of individual investigators to conduct cutting edge research in the vision sciences.
Our Aims are: 1) to provide resources, support and training required for conducting studies involving mass spectrometry, molecular and cell biology techniques at the level exceeding the capabilities of any individual laboratory; 2) to promote collegiality across the community of vision scientists through sharing resources, techniques and expertise; and 3) to engage colleagues into conducting vision research, including support of the next generation of basic and clinician scientists. To achieve these Aims, this Module will support sophisticated facilities equipped with state-of-the-art instrumentation and cutting edge software support. The Module will be supervised and operated by highly experienced personnel, with expertise in conducting a broad array of mass spectrometry and other molecular techniques, including but not limited to proteomics, mass spectrometry of small molecules, RT-PCR, quantitative fluorescent imaging and tissue culture. These shared resources will open new research possibilities for both experienced and novice users, and will serve as a platform for fostering interactions among a broad swath of our research community.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY005722-35
Application #
10006547
Study Section
Special Emphasis Panel (ZEY1)
Project Start
1997-07-01
Project End
2021-08-31
Budget Start
2020-09-01
Budget End
2021-08-31
Support Year
35
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Wang, Ke; Li, Guorong; Read, A Thomas et al. (2018) The relationship between outflow resistance and trabecular meshwork stiffness in mice. Sci Rep 8:5848
Sharif, Ali S; Yu, Dongmei; Loertscher, Stuart et al. (2018) C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis. J Neurosci 38:3160-3176
Yiu, Glenn; Wang, Zhe; Munevar, Christian et al. (2018) Comparison of chorioretinal layers in rhesus macaques using spectral-domain optical coherence tomography and high-resolution histological sections. Exp Eye Res 168:69-76
Li, Guorong; Torrejon, Karen Y; Unser, Andrea M et al. (2018) Trabodenoson, an Adenosine Mimetic With A1 Receptor Selectivity Lowers Intraocular Pressure by Increasing Conventional Outflow Facility in Mice. Invest Ophthalmol Vis Sci 59:383-392
Willoughby, Alex S; Vuong, Vivian S; Cunefare, David et al. (2018) Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion. Am J Ophthalmol 186:144-151
Soltanian-Zadeh, Somayyeh; Gong, Yiyang; Farsiu, Sina (2018) Information-Theoretic Approach and Fundamental Limits of Resolving Two Closely Timed Neuronal Spikes in Mouse Brain Calcium Imaging. IEEE Trans Biomed Eng 65:2428-2439
Smit-McBride, Zeljka; Nguyen, Johnny; Elliott, Garrett W et al. (2018) Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque. Mol Vis 24:633-646
Lobanova, Ekaterina S; Finkelstein, Stella; Li, Jing et al. (2018) Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. Nat Commun 9:1738
Parolini, Barbara; Grewal, Dilraj S; Pinackatt, Sajish J et al. (2018) COMBINED AUTOLOGOUS TRANSPLANTATION OF NEUROSENSORY RETINA, RETINAL PIGMENT EPITHELIUM, AND CHOROID FREE GRAFTS. Retina 38 Suppl 1:S12-S22
Malek, Goldis; Busik, Julia; Grant, Maria B et al. (2018) Models of retinal diseases and their applicability in drug discovery. Expert Opin Drug Discov 13:359-377

Showing the most recent 10 out of 437 publications