- PROTEOMICS AND MASS SPECTROMETRY CORE This National Eye Instituted-funded Proteomics and Mass Spectrometry Core has the long-term objective of using the very latest technologies in the field of proteomics to discover the causes of eye disease, including cataract, glaucoma, age-related macular degeneration, and devise better treatments. Mass spectrometric analysis of proteins will be performed with the specific aims of measuring changes in the abundance of proteins, how proteins fold and interact with one another, and how they become modified in both health and disease. The methods employed will include hydrogen-deuterium exchange to measure solvent accessibility in proteins, chemical cross-linking to define where proteins interact, tandem mass tagging to detect proteins undergoing changes in abundance, and phosphopeptide analysis to discover mechanisms controlling cellular processes. The proposed studies will take advantage of a newly installed state-of-the-art high-resolution mass spectrometer. The results will complement data generated by the other modules supported by this P30 grant to increase the productivity of vision researchers at OHSU and devise better treatments for eye disease.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY010572-22
Application #
9129701
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-09-01
Budget End
2017-08-31
Support Year
22
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Jayaram, Hari; Lozano, Diana C; Johnson, Elaine C et al. (2018) Investigation of MicroRNA Expression in Experimental Glaucoma. Methods Mol Biol 1695:287-297
Park, Dong-Wouk; Alonzo, Brock; Faridi, Ambar et al. (2018) MULTIMODAL IMAGING OF PHOTIC MACULOPATHY FROM ARC WELDING. Retin Cases Brief Rep :
Berry, Duncan E; Schefler, Amy C; Seider, Michael I et al. (2018) CORRELATION OF GENE EXPRESSION PROFILE STATUS AND AMERICAN JOINT COMMISSION ON CANCER STAGE IN UVEAL MELANOMA. Retina :
Choi, Rene Y; Rivera-Grana, Erick; Rosenbaum, James T (2018) Reclassifying Idiopathic Uveitis: Lessons from a Tertiary Uveitis Center. Am J Ophthalmol :
Young, Jonathan W; Clements, John L; Morrison, John C et al. (2018) Brinzolamide-induced Follicular Conjunctivitis. J Glaucoma 27:e183-e184
Henriksen, Brad; Perry, C Blake; Ng, John D (2018) The Narrow-Lumen Jones Tube: A Novel Approach to Dry Eye Following Conjunctivodacryocystorhinostomy. Ophthalmic Plast Reconstr Surg 34:e123-e124
Krey, Jocelyn F; Scheffer, Deborah I; Choi, Dongseok et al. (2018) Mass spectrometry quantitation of proteins from small pools of developing auditory and vestibular cells. Sci Data 5:180128
Tan, Ou; Liu, Liang; Liu, Li et al. (2018) Nerve Fiber Flux Analysis Using Wide-Field Swept-Source Optical Coherence Tomography. Transl Vis Sci Technol 7:16
Tehrani, Shandiz; Delf, R Katherine; Cepurna, William O et al. (2018) In Vivo Small Molecule Delivery to the Optic Nerve in a Rodent Model. Sci Rep 8:4453
Lockhart, Catherine M; Smith, Travis B; Yang, Paul et al. (2018) Longitudinal characterisation of function and structure of Bietti crystalline dystrophy: report on a novel homozygous mutation in CYP4V2. Br J Ophthalmol 102:187-194

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