Abstract

- PROTEOMICS AND MASS SPECTROMETRY CORE This National Eye Instituted-funded Proteomics and Mass Spectrometry Core has the long-term objective of using the very latest technologies in the field of proteomics to discover the causes of eye disease, including cataract, glaucoma, age-related macular degeneration, and devise better treatments. Mass spectrometric analysis of proteins will be performed with the specific aims of measuring changes in the abundance of proteins, how proteins fold and interact with one another, and how they become modified in both health and disease. The methods employed will include hydrogen-deuterium exchange to measure solvent accessibility in proteins, chemical cross-linking to define where proteins interact, tandem mass tagging to detect proteins undergoing changes in abundance, and phosphopeptide analysis to discover mechanisms controlling cellular processes. The proposed studies will take advantage of a newly installed state-of-the-art high-resolution mass spectrometer. The results will complement data generated by the other modules supported by this P30 grant to increase the productivity of vision researchers at OHSU and devise better treatments for eye disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY010572-23
Application #
9332449
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
23
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Loh, Allison R; Edmunds, Beth; Peter Campbell, J et al. (2018) Ophthalmic imaging in children: current practice patterns and perceived barriers. J AAPOS 22:223-225.e3
Hagag, Ahmed M; Pechauer, Alex D; Liu, Liang et al. (2018) OCT Angiography Changes in the 3 Parafoveal Retinal Plexuses in Response to Hyperoxia. Ophthalmol Retina 2:329-336
Lu, Yansha; Simonett, Joseph M; Wang, Jie et al. (2018) Evaluation of Automatically Quantified Foveal Avascular Zone Metrics for Diagnosis of Diabetic Retinopathy Using Optical Coherence Tomography Angiography. Invest Ophthalmol Vis Sci 59:2212-2221
Kim, Sang Jin; Port, Alexander D; Swan, Ryan et al. (2018) Retinopathy of prematurity: a review of risk factors and their clinical significance. Surv Ophthalmol 63:618-637
Adamus, Grazyna (2018) Are Anti-Retinal Autoantibodies a Cause or a Consequence of Retinal Degeneration in Autoimmune Retinopathies? Front Immunol 9:765
Watson, Spencer S; Dane, Mark; Chin, Koei et al. (2018) Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. Cell Syst 6:329-342.e6
Windsor, Matthew A; Sun, Sissi J J; Frick, Kevin D et al. (2018) Estimating Public and Patient Savings From Basic Research-A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy. Am J Ophthalmol 185:115-122
Shahidi, Mahnaz; Felder, Anthony E; Tan, Ou et al. (2018) Retinal Oxygen Delivery and Metabolism in Healthy and Sickle Cell Retinopathy Subjects. Invest Ophthalmol Vis Sci 59:1905-1909
Hirji, Nashila; Bradley, Patrick D; Li, Shuning et al. (2018) Jalili Syndrome: Cross-sectional and Longitudinal Features of Seven Patients With Cone-Rod Dystrophy and Amelogenesis Imperfecta. Am J Ophthalmol 188:123-130
McGill, Trevor J; Stoddard, Jonathan; Renner, Lauren M et al. (2018) Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates. Invest Ophthalmol Vis Sci 59:1374-1383

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