In the previous funding period, Histology was administratively part of the Tissue Culture and Cell Analysis Module; however, due to changes in investigator needs, increased microscopy and imaging capacity, we have now combined Histology with Imaging and added Microscopy. The Histology, Microscopy and Imaging (HMI) Module will occupy two rooms jn the consolidated VSRC Core Grant facility in the Institute of Pathology, with a third room containing animal photography equipment. Three highly qualified individuals will conduct the functions for this Module: Scott Howell, Ph.D. will manage the overall functions of the Module and specifically work with the moderate and extensive users for the Microscopy and Imaging functions of the Module including laser capture microscopy (LCM);Catherine Doller will be in charge of the Histology facility as Co-Manager, and Mark Harrod, the Imaging Manager in the previous funding period, will remain on a part-time basis to oversee the animal photography functions as Co-Manager of the Digital Imaging function. This Module will also be responsible for updating the VSRC website www.case.edu/med/vsrc/.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY011373-13
Application #
7805447
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2009-05-01
Budget End
2010-04-30
Support Year
13
Fiscal Year
2009
Total Cost
$285,453
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Basak, Sandip; Gicheru, Yvonne; Rao, Shanlin et al. (2018) Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor. Nature 563:270-274
Gao, Songqi; Parmar, Tanu; Palczewska, Grazyna et al. (2018) Protective Effect of a Locked Retinal Chromophore Analog against Light-Induced Retinal Degeneration. Mol Pharmacol 94:1132-1144
Malemud, Charles J (2018) The role of the JAK/STAT signal pathway in rheumatoid arthritis. Ther Adv Musculoskelet Dis 10:117-127
Clark, Heather L; Minns, Martin S; Sun, Yan et al. (2018) Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis. Invest Ophthalmol Vis Sci 59:1589-1598
Parmar, Tanu; Parmar, Vipul M; Perusek, Lindsay et al. (2018) Lipocalin 2 Plays an Important Role in Regulating Inflammation in Retinal Degeneration. J Immunol 200:3128-3141
Widjaja-Adhi, Made Airanthi K; Ramkumar, Srinivasagan; von Lintig, Johannes (2018) Protective role of carotenoids in the visual cycle. FASEB J :fj201800467R
Chen, Yuanyuan; Chen, Yu; Jastrzebska, Beata et al. (2018) A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun 9:1976
Mast, Natalia; Bederman, Ilya R; Pikuleva, Irina A (2018) Retinal Cholesterol Content Is Reduced in Simvastatin-Treated Mice Due to Inhibited Local Biosynthesis Albeit Increased Uptake of Serum Cholesterol. Drug Metab Dispos 46:1528-1537
Hughes, Taylor E T; Lodowski, David T; Huynh, Kevin W et al. (2018) Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM. Nat Struct Mol Biol 25:53-60
Hughes, Taylor E T; Pumroy, Ruth A; Yazici, Aysenur Torun et al. (2018) Structural insights on TRPV5 gating by endogenous modulators. Nat Commun 9:4198

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