Research Plan The University of California at Davis provides a n environment that fosters multidisciplinary research excellence to address fundamental questions on the NEI health and science agendas. UC Davis annually trains the largest number of biological science PhD's in the nation, and is home to one of the nation's fastest growing medical schools, top ranked School of Veterinary Medicine and long recognized College of Biological Sciences. Our campus is geographically the largest of the ten campuses of the UC system, and the National Science Foundation ranks Davis as first among the UCs for funding in the biological sciences. UC Davis is also ranked 6* among all U.S. universities for contributions to society {Washington Monthly, 2010), 4* among U.S. universities in number of international scholars {Open Doors 2008 Report on International Educational Exchange) and is the 17* most racially and ethnically diverse large research university {U.S. News and World Report, 2009). Total enrollment is over 24,750 undergraduates and ~7,553 graduate and professional students, the third largest in the UC System. Partly because of space limitations at most other UC campuses, the Davis campus has been targeted for continued growth. Vision science has been, and is expected to continue to be, a major beneficiary of this growth. This proposal seeks continued funding for the NEI Core grant at UC Davis. Since it was initially funded in 1998, this Core grant has played a critical role in the growth of vision research on our campus, and we anticipate that it will continue to do so in the foreseeable future. Vision science at UC Davis now includes 35 investigators, across 14 departments, each with extensive individual facilities, extramural support, and research programs which collectively cover a broad range of areas including genetics, molecular biology, optics, retinal anatomy and physiology, central mechanism physiology and behavior, computational modeling, and perception. UC Davis has a long history of support for integration across disciplines that is facilitated by large-scale resources for basic and translational research that are available to our vision scientists. Selected examples follow: (1) The Mouse Biology Program makes nearly 200 genetically altered mice strains and more than 5,000 embryonic-stem cell derived knockout strains. Several of our Core investigators (Burns, Glaser, Cheng) use mice from this program. (2) The California National Primate Research Center is one of the largest of the eight NIH-funded regional facilities, housing more than 6,000 nonhuman primates. It supports the research of two Core investigators studying visual cortex (Britten, Usrey). (3) The Center f o r Neuroscience provides laboratory space for 25 faculty members and has made vision science a priority. It houses several Core investigators (Britten, Cheng, Krubitzer, Usrey) and provides dedicated space for the Software Engineering Core. It includes three buildings (55,000 ft 2) containing offices, vivaria and labs for the study of awake behaving monkeys, as well as a newly installed 3T Skyra MRI scanner configured for structural and functional imaging studies of human and non-human primates. (4) The Center for Mind and Brain is a university initiative providing more than 30,000 ft 2 of custom-designed facilities dedicated to investigations of higher-level perception and cognition. One member of this Center (Oakes) has a Core-eligible R01, while two other vision scientists in this Center are supported by NSF and NIMH. (5) The Departments of Ophthalmology in the School of Medicine (SOM) and the School of Veterinary Medicine (SVM) devote considerable resources for vision research. Ophthalmology in the SOM serves as the primary research site for 26 faculty. Administrative support is provided for this Core grant in space adjacent to the Pi's office and laboratories (~2,500 ft 2). Ophthalmology in the SVM has the largest collection of board-certified ophthalmologists in the nation, and includes four faculty, and one NEI KO-8 funded DVM-PhD. Recently renovated research space (~2,400 ft2) contains multiple examination and procedures rooms, and provides shared support for optical and retinal phenotyping of a range of animal species. It is shared with vision scientists outside the SVM. (6) The Clinical and Translational Science Center is one of 12 founding NIH Clinical and Translational Science Centers nationwide that were awarded in 2006. It is housed in a specially renovated, 16,000 ft 2 facility to support collaborations between basic and applied vision scientists. It has supported several projects by clinical vision scientists at UC Davis (Keltner, Lim, Park). (7) The California Institute for Regenerative Cures serves as a hub for basic, translational, and clinical regenerative medicine and includes the UC Davis Stem Cell Program that provides scale-up services for clinical cellular therapy trials to be performed in the Good Manufacturing Practice facility, the only one in Northern California. This facility houses the laboratory of a recently hired NEI Core researcher (Zhao). These resources make UC Davis uniquely poised for continued excellence in the basic sciences and growth in translational research in the vision sciences. The cores proposed here will facilitate this growth.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Center Core Grants (P30)
Project #
5P30EY012576-18
Application #
9084574
Study Section
Special Emphasis Panel (ZEY1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
18
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Azimi, Mina; Le, Tien T; Brown, Nadean L (2018) Presenilin gene function and Notch signaling feedback regulation in the developing mouse lens. Differentiation 102:40-52
Thomasy, Sara M; Raghunathan, Vijay Krishna; Miyagi, Hidetaka et al. (2018) Latrunculin B and substratum stiffness regulate corneal fibroblast to myofibroblast transformation. Exp Eye Res 170:101-107
Miyagi, Hidetaka; Jalilian, Iman; Murphy, Christopher J et al. (2018) Modulation of human corneal stromal cell differentiation by hepatocyte growth factor and substratum compliance. Exp Eye Res 176:235-242
Partida, Gloria J; Fasoli, Anna; Fogli Iseppe, Alex et al. (2018) Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve. J Neurosci 38:8087-8105
Swarup, Aditi; Bell, Brent A; Du, Jianhai et al. (2018) Deletion of GLUT1 in mouse lens epithelium leads to cataract formation. Exp Eye Res 172:45-53
Kowalchuk, Angelica M; Maurer, Kate A; Shoja-Taheri, Farnaz et al. (2018) Requirements for Neurogenin2 during mouse postnatal retinal neurogenesis. Dev Biol 442:220-235
Usrey, W Martin; Sherman, S Murray (2018) Corticofugal circuits: Communication lines from the cortex to the rest of the brain. J Comp Neurol :
Failor, Samuel Wilson; Ng, Arash; Cheng, Hwai-Jong (2018) Monocular enucleation alters retinal waves in the surviving eye. Neural Dev 13:4
Yiu, Glenn; Wang, Zhe; Munevar, Christian et al. (2018) Comparison of chorioretinal layers in rhesus macaques using spectral-domain optical coherence tomography and high-resolution histological sections. Exp Eye Res 168:69-76
Smit-McBride, Zeljka; Nguyen, Johnny; Elliott, Garrett W et al. (2018) Effects of aging and environmental tobacco smoke exposure on ocular and plasma circulatory microRNAs in the Rhesus macaque. Mol Vis 24:633-646

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