The Center for Alaska Native Health Research (CANHR), established in 2001 with COBRE I support, has become nationally recognized for both the quality of its research to reduce disease and promote health among Alaska Native (AN) people and for Community-Based Participatory Research (CBPR) with minority populations. AN people have been engaged in all phases of CANHR research, including setting CANHR's current research agenda on obesity and metabolic disease. The evolution and solidification of this decade-long community partnership has expanded this research agenda into intervention research aimed at prevention and treatment of obesity and metabolic disease, youth suicide, and substance abuse. CANHR funding has increased from one NIH grant in 2001, to nearly $5M in 2010. With support from an NIH construction grant, we are building the first two clinical research laboratories in the state of Alaska, while increasing our net space by over 5,000 sq. ft. The University of Alaska Fairbanks leadership has increased its already substantial commitment to CANHR, further augmenting our research expertise with new faculty hires and consultation from nationally recognized senior researchers through the President's Professors program. Our publication rate continues to increase, surpassing 100 publications in the past four years. The goal of the proposed COBRE Phase III Transitional Center is to solidify these achievements with a focus on transitioning CANHR into a self-supporting, sustainable, nationally recognized research center focused on AN health and CBPR. We propose to do this by: (1) strengthening the infrastructure of core resources to support research and community engagement;(2) expanding mentoring and training opportunities to develop the next generation of AN health researchers;(3) developing an innovative Pilot Project program (External Partnerships for Specific Expertise), to foster collaborative research with scientific leaders at research-intensive institutions that, in our experience, will p9sitively impact our extramural funding success;(4) continuing the President's Professors Program to expand intellectual capital and national recognition of CANHR;and (5) including a comprehensive business plan to ensure income to sustain CANHR cores.

Public Health Relevance

A key goal of our center is to work with community partners to develop a research agenda and use the research results to better understand the causes and contributing factors of diseases faced by Alaska Native people, and their prevention and treatment. This will enhance the potential for the successful deployment of culturally respectful community-based interventions that will provide evidence-based health practices for Alaska Native people.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Center Core Grants (P30)
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Special Emphasis Panel (ZRR1-RI-B (01))
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Liu, Yanping
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University of Alaska Fairbanks
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Au, Nicholas T; Ryman, Tove; Rettie, Allan E et al. (2018) Dietary Vitamin K and Association with Hepatic Vitamin K Status in a Yup'ik Study Population from Southwestern Alaska. Mol Nutr Food Res 62:
O'Brien, Kristin M; Crockett, Elizabeth L; Philip, Jacques et al. (2018) The loss of hemoglobin and myoglobin does not minimize oxidative stress in Antarctic icefishes. J Exp Biol 221:
Ryman, Tove K; Boyer, Bert B; Hopkins, Scarlett E et al. (2018) Association between iq'mik smokeless tobacco use and cardiometabolic risk profile among Yup'ik Alaska Native people. Ethn Health 23:488-502
Sticka, Kendra D; Schnurr, Theresia M; Jerome, Scott P et al. (2018) Exercise Increases Glucose Transporter-4 Levels on Peripheral Blood Mononuclear Cells. Med Sci Sports Exerc 50:938-944
Maurice, Anne-Claire; Philip, Jacques; Bersamin, Andrea (2017) Yup'ik identity and socioeconomic status are associated with child consumption of traditional food and weight in rural Yup'ik communities. Ethn Health :1-11
Koller, Kathryn R; Flanagan, Christie A; Day, Gretchen E et al. (2017) High tobacco use prevalence with significant regional and sex differences in smokeless tobacco use among Western Alaska Native people: the WATCH study. Int J Circumpolar Health 76:1398009
Philip, Jacques; Ryman, Tove K; Hopkins, Scarlett E et al. (2017) Bi-cultural dynamics for risk and protective factors for cardiometabolic health in an Alaska Native (Yup'ik) population. PLoS One 12:e0183451
O'Brien, Diane M; Thummel, Kenneth E; Bulkow, Lisa R et al. (2017) Declines in traditional marine food intake and vitamin D levels from the 1960s to present in young Alaska Native women. Public Health Nutr 20:1738-1745
Fohner, Alison E; Wang, Zhican; Yracheta, Joseph et al. (2016) Genetics, Diet, and Season Are Associated with Serum 25-Hydroxycholecalciferol Concentration in a Yup'ik Study Population from Southwestern Alaska. J Nutr 146:318-25
Philip, Jacques; Ford, Tara; Henry, David et al. (2016) Relationship of Social Network to Protective Factors in Suicide and Alcohol Use Disorder Intervention for Rural Yup'ik Alaska Native Youth. Interv Psicosoc 25:45-54

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